多发性硬化与视神经脊髓炎谱系疾病的电生理改变研究进展  

Advances in the Study of Electrophysiological Alterations in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

作　　者：谭裕玲 杨双凤 涂敏 王晓明[1,2] TAN Yuling;YANG Shuangfeng;TU Min;WANG Xiaoming(Department of Neurology,Affiliated Hospital of Chuanbei Medical College,Nanchong,Sichuan Province,637000 China;Institute of Neurological Diseases,Chuanbei Medical College,Nanchong,Sichuan Province,637000 China)

机构地区：[1]川北医学院附属医院神经内科,四川南充637000 [2]川北医学院神经疾病研究所,四川南充637000

出　　处：《世界复合医学》2023年第1期194-198,共5页World Journal of Complex Medicine

基　　金：基于“互联网+”急危重症心脑血管病救治平台建设(19SXHZ0431);南充市脑功能修复与调控重点实验室建设项目(NCKL201906)。

摘　　要：多发性硬化(multiple sclerosis,MS)和视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)是免疫介导的原发性中枢神经系统炎性脱髓鞘疾病。MS主要是由细胞免疫引起的,而NMOSD存在直接针对水通道蛋白4的抗体(AQP4-IgG)。MS的病变主要影响皮质旁、脑室周围、脑干、脊髓等,而NMOSD主要以视神经和脊髓为靶点。在临床上,神经电生理检查具有一定程度的客观性,可以应用于MS和NMOSD患者,以确定相关的神经通路有无损伤及其相应的损伤部位,通过对其分析,有助于判断疾病的临床阶段和严重程度。本文就MS与NMOSD的相关神经电生理进行综述。Multiple sclerosis(MS)and optic neuromyelitis optica spectrum disorders(NMOSD)are immune-mediated primary inflammatory demyelinating diseases of the central nervous system.MS is mainly caused by cellular immunity.While antibodies directly targeting aquaporin 4(AQP4-IgG)are present in NMOSD.Lesions in MS mainly affect the paracortex,periventricular,brainstem,and spinal cord,while NMOSD mainly targets the optic nerve and spinal cord.In clinical practice,neurophysiological examination has a certain degree of objectivity and can be applied to patients with MS and NMOSD to determine the presence or absence of damage to the relevant neural pathways and their corresponding injury sites,and its analysis can help determine the clinical stage and severity of the disease.This review summarizes the relevant neurophysiology associated with MS and NMOSD.

关 键 词：多发性硬化 视神经脊髓炎谱系疾病 电生理学 

分 类 号：R4[医药卫生—临床医学]