和厚朴酚的心血管药理作用研究进展  

Research advance on cardiovascular pharmacologic effect of honokiol

作　　者：张明发[1] 沈雅琴[1] ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《药物评价研究》2023年第3期683-692,共10页Drug Evaluation Research

摘　　要：和厚朴酚是二酚型疏水化合物,对糖尿病、血管紧张素II、脓毒症、烧伤、冠脉结扎缺血、缺血再灌注等引起的心肌损伤都有保护作用,能阻滞心肌肥厚和纤维化的发生发展。和厚朴酚能拮抗脂多糖或氧化型低密度脂蛋白引起的血管内皮细胞损伤,也能抑制血管平滑肌细胞增殖、迁移及血管重塑和血管新生,抑制气囊血管形成术诱导新内膜形成和血管狭窄,心血管保护作用的基本机制是抗氧化、抗炎、调血脂、降血糖和阻滞钙通道。和厚朴酚可以抑制高脂饮食引起的动脉粥样硬化形成和发展,还具有血管扩张和降压作用,因此在心血管系统疾病治疗方面有开发价值。Honokiol is a hydrophobic compound of biphenol-type structure,and inhibit neointima formation and vascular stenosis induced by balloon angiogenesis.has the protective action against myocardial injury induced by diabetes,angiotensin II,sepsis,burned,coronary artery ligature-induced ischemia,and ischemia/reperfusion,and can block to occurrence and development of myocardial hypertrophy and fibrosis.Honokiol antagonizes lipopolysaccharides or ox-LDL-induced vascular endothelial cells injury,and inhibits proliferation and migration of vascular smooth muscle cells,and vascular remodeling and neovascularization.The basic mechanisms of cardiovascular protection of honokiol are antioxidation,anti-inflammation,hypoglycemia,hypolipidemia and blocking Ca2+channel.It relieves hyperliposis diet-induced atherosclerosis,also has vascular dilation and antihypertensive effects.It has development value in the treatment of cardiovascular system diseases.

关 键 词：和厚朴酚 心血管系统 心肌损伤 动脉粥样硬化 降压 

分 类 号：R287.5[医药卫生—中药学]