猪胸膜肺炎杆菌免疫机制研究进展  

Research Progress on Immune Mechanism of Actinobacillus pleuropneumoniae

作　　者：张一帜 张媛[1] 李建[1] 王秀丽[1] 刘元杰 任小侠[1] 辛凌翔[1] 宋佳诚 罗玉峰[1] ZHANG Yi-zhi;ZHANG Yuan;LI Jian;WANG Xiu-li;LIU Yuan-jie;REN Xiao-xia;XIN Ling-xiang;SONG Jia-cheng;LUO Yu-feng(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京海淀100081

出　　处：《中国兽医杂志》2023年第4期80-84,共5页Chinese Journal of Veterinary Medicine

摘　　要：猪传染性胸膜肺炎由胸膜肺炎放线杆菌(App)感染引起,影响猪的呼吸系统,死亡率高,在世界范围内造成猪业的重大经济损失。临床研究发现,部分野生株App对于常规抗生素具有耐药性,这为该病的防治带来严峻的挑战。本文梳理了近年来App感染过程中宿主免疫应答方面的相关研究,从先天性免疫、体液免疫和细胞免疫3个方面,探讨该菌的感染机理和免疫原性,以期为猪传染性胸膜肺炎的防控和疫苗研究提供参考。Porcine pleuropneumonia is caused by Actinobacillus pleuropneumoniae(A.pleuropneumoniae),which affects the respiratory system of pigs,causes a high mortality,and accounts for significant economic losses in the pig industry worldwide.Previous reports have shown that some A.pleuropneumoniae strains are resistant to common antibiotics,and pose severe challenges to the prevention and treatment of the disease.This article reviews the latest research on the host immune responses during A.pleuropneumoniae infection,discusses the infection mechanism and immunogenicity of A.pleuropneumoniae in relation to innate,humoral and cellular immunity,and hopes to provide theoretical and practical supports for the prevention and control of pleuropneumonia,and guide the study on vaccine development and improvement.

关 键 词：猪传染性胸膜肺炎 胸膜肺炎放线杆菌 先天性免疫 体液免疫 细胞免疫 

分 类 号：S855.1[农业科学—临床兽医学]