基于数据挖掘《古今名医临证金鉴·痿证卷》治疗痿证用药规律  

Research on Medication Rules of GujinMingyiLinzhengJinjian,Weizheng Juanin the Treatment of Flaccidity Syndrome Based on Data Mining

作　　者：宋港 李纯根 邝涛[1] 蒋勇 廖怀章 Song Gang;Li Chungen;Kuang Tao;Jiang Yong;Liao Huaizhang(The First Hospital Affiliated to Hunan University of Chinese Medicine,Changsha 410007,China;Zhengda Shaoyang Orthopedics Hospital,Shaoyang 422900,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]正大邵阳骨伤科医院,湖南邵阳422900

出　　处：《亚太传统医药》2023年第4期149-155,共7页Asia-Pacific Traditional Medicine

基　　金：全国基层名老中医药专家传承工作室建设项目(国中医药人教函[2019]42号);湖南省中医药科研计划项目(2020089);“十三五”省级中医重点专科建设项目(430S00/2017-78136);湖南中医药大学研究生创新课题(2021CX71/0002012071)。

摘　　要：目的:探究《古今名医临证金鉴·痿证卷》治疗痿证的用药规律,为临床辨治拓展思路。方法:整理《古今名医临证金鉴·痿证卷》中历代医家论治痿证的有效经验方,借助Excel 2010将复方录入整理成数据库,运用Excel 2010、Microsoft Power BI 2022进行频次分析,SPSS Modeler 18.0进行关联规则分析,SPSS Statistics 26.0进行聚类以及因子分析。结果:最终纳入258首方剂,涉及中药296味,以当归、甘草、牛膝、茯苓、熟地黄等为核心药物,药性以温、寒、平为主,药味以甘、苦、辛为主,归经以肝、肾、脾、肺为主,功效以补肝肾、健脾益气、强筋骨为要;关联规则分析白术、当归组合支持度最高;因子分析共获得白芍、当归、黄芪、熟地黄等5个公因子;聚类分析获得麦冬、人参、生地黄等4个聚类方。结论:从多角度总结《古今名医临证金鉴·痿证卷》治疗痿证用药规律及特征,为临床实践提供借鉴。Objective:To explore the rule of medication in the treatment of flaccidity syndrome in Gujin Mingyi Linz-heng Jinjian,Weizheng Juan.Methods:The effective empirical prescriptions of Gujin Mingyi Linzheng Jinjian,Weizheng Juan were sorted and input into Excel 2010for establishing a database,using Excel 2010and Microsoft Pow-er BI 2022for frequency analysis,SPSS Modeler 18.0for association rule analysis,SPSS Statistics 26.0for clustering analysis and factor analysis.Results:258empirical prescriptions,involving 296Chinese Herbs,with Danggui,Gancao,Niuxi,Fuling and Shudihuang as the core herbs.They,mainly Wen,Han,and Ping in Xing,and Gan,Kuang Xin in Wei,are closely related to Ganjing,Shenjing,Pijing and Feijing.Most of herbs were selected for Buganshen,Jianpi,Yiqi,Qiangjingu.The Baizhu-Danggui combination has the highest support in association rule analysis.five common factors were extracted,such as Baishao,Danggui,Huangqi,Shudihuang.According to clustering analysis,The herbs could be classified into four clusters,such as Maidong,Renshen and Shengdihuang.Conclusion:Through muti angles research and analysis of Gujin Mingyi Linzheng Jinjian,Weizheng Juan,the rule and characteristics of medication in the treat-ment of flaccidity syndrome,to provides reference for clinical practice.

关 键 词：古今名医 痿证 数据挖掘 用药规律 

分 类 号：R255.6[医药卫生—中医内科学]