6种清热解毒类中药注射液治疗儿童毛细支气管炎的贝叶斯网状Meta分析  

Bayesian network Meta-analysis of six kinds of heat-clearing and detoxifying Chinese medicine injections in treatment of children with bronchiolitis

作　　者：王丹[1] 史宏硕 王宗浩 彭健 司国民 WANG Dan;SHI Hongshuo;WANG Zonghao;PENG Jian;SI Guomin(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Traditional Chinese Medicine,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250000,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东第一医科大学附属省立医院中医科,山东济南250000

出　　处：《药物评价研究》2023年第2期430-444,共15页Drug Evaluation Research

基　　金：山东省中医药科技发展计划项目(2019-0298);山东省名老中医药专家司国民传承工作室项目(鲁卫函[2019]92)。

摘　　要：目的系统评价6种清热解毒类中药注射液联合常规西医治疗儿童毛细支气管炎的疗效与安全性。方法计算机检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、CBM、Web of Science、The Cochrane Library、PubMed和Embase数据库收录的清热解毒类中药注射液治疗儿童毛细支气管炎的随机对照试验(RCT),检索时间均自建库至2021年3月14日。提取合格文献相关信息,通过Cochrane风险偏倚评价工具对纳入研究进行质量评价。使用R软件、JAGS软件和GEMTC软件包进行贝叶斯网状Meta分析。结果最终纳入26项RCTs,涉及2776例患儿及喜炎平注射液、炎琥宁注射液、血必净注射液、热毒宁注射液、痰热清注射液、鱼腥草注射液6种清热解毒类中药注射液。网状Meta分析结果显示,与常规西医治疗相比,(1)提高临床总有效率方面,喜炎平注射液>炎琥宁注射液>血必净注射液>热毒宁注射液>痰热清注射液>鱼腥草注射液;(2)缩短憋喘时间方面,喜炎平注射液>痰热清注射液>热毒宁注射液>炎琥宁注射液>血必净注射液;(3)缩短咳嗽时间方面,热毒宁注射液>痰热清注射液>喜炎平注射液>血必净注射液;(4)肺部啰音消失方面,喜炎平注射液>鱼腥草注射液>热毒宁注射液>血必净注射液>炎琥宁注射液>痰热清注射液;(5)肺部哮鸣音消失方面,喜炎平注射液>热毒宁注射液>炎琥宁注射液>血必净注射液>痰热清注射液;(6)缩短平均住院时间方面,喜炎平注射液>炎琥宁注射液>热毒宁注射液>血必净注射液>鱼腥草注射液>痰热清注射液。6种清热解毒类中药注射液在治疗过程中均未产生严重不良反应。结论现有证据表明,清热解毒类中药注射液联合西医常规治疗可提高儿童毛细支气管炎的疗效,其中以喜炎平注射液总体治疗效果较好。Objective To systematically evaluate the clinical effect and safety of six kinds of heat-clearing and detoxifying Chinese medicine injection in treatment of children with bronchiolitis.Methods Randomized controlled trial(RCT)on treatment of children with bronchiolitis by heat-clearing and detoxifying Chinese medicine injections were retrieved from eight databases including CNKI and PubMed(from establishment to March 14,2021).Related information in eligible articles was extracted,and the quality of the included articles was assessed by Cochrane collaboration’s tool for assessing risk of bias.R software,JAGS software and GEMTC software package was used for Bayesian network Meta-analysis.Results A total of 26 eligible studies were screened out,involving 2776 patients and six kinds of heat-clearing and detoxifying Chinese medicine injection:Xiyanping Injection,Potassium Sodium Dehydroandrographolide Succinat Injection,Xuebijing Injection,Reduning Injection,Tanreqing Injection,Houttuynia Cordata Injection.According to the statistical difference and network Meta-analysis,compared with the treatment of conventional medicine alone,the injections are in the order of(1)Xiyanping Injection>Potassium Sodium Dehydroandrographolide Succinat Injection>Xuebijing Injection>Reduning Injection>Tanreqing Injection>Houttuynia Cordata Injection in improving the clinical effective rate.(2)Xiyanping Injection>Tanreqing Injection>Reduning Injection>Potassium Sodium Dehydroandrographolide Succinat Injection>Xuebijing Injection to the relief of wheezing.(3)Reduning Injection>Tanreqing Injection>Xiyanping Injection>Xuebijing Injection to the relief of cough.(4)Xiyanping Injection>Houttuynia Cordata Injection>Reduning Injection>Xuebijing Injection>Potassium Sodium Dehydroandrographolide Succinat Injection>Tanreqing Injection to the relief of lung rale.(5)Xiyanping Injection>Reduning Injection>Potassium Sodium Dehydroandrographolide Succinat Injection>Xuebijing Injection>Tanreqing Injection to relief of lung auscultation.(6)Xiyanping Inject

关 键 词：毛细支气管炎 儿童 中药注射液 清热解毒 网状Meta分析 贝叶斯 喜炎平注射液 炎琥宁注射液 血必净注射液 热毒宁注射液 痰热清注射液 鱼腥草注射液 

分 类 号：R975[医药卫生—药品]