白藜芦醇抗肿瘤药理作用机制研究进展  

Research progress in antitumor mechanism of resveratrol

作　　者：王真 陈立伟[1,2] WANG Zhen;CHEN Liwei(Department of Oncology,First Teaching Hospital of Tianjin University of Treatment Chinese Medicine,Tianjin 300380,China;National Clinical Research Center for Chinese Medicine Acuuncture and Moxibustion,Tianjin 300380,China)

机构地区：[1]天津中医药大学第一附属医院肿瘤科,天津300380 [2]国家中医针灸临床医学研究中心,天津300380

出　　处：《药物评价研究》2023年第2期445-451,共7页Drug Evaluation Research

基　　金：国家重点研发计划资助项目(2018YFC1707410-03)。

摘　　要：白藜芦醇是一种天然单体化合物,属于非黄酮类的多酚化合物,存在于多种植物中。现代药理研究发现,白藜芦醇具有抗炎、抗氧化、抗肿瘤、调节代谢与机体免疫等药理活性。白藜芦醇对结肠癌、胰腺癌、卵巢癌、乳腺癌等多种肿瘤细胞均有抑制作用,其抗肿瘤作用逐渐成为研究热点。白藜芦醇可以通过抑制肿瘤细胞的增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭和转移、调节机体免疫功能、直接作用于相关靶点等发挥抗肿瘤活性。就白藜芦醇在不同肿瘤细胞中发挥的抗肿瘤作用及其机制进行综述,以期为抗肿瘤新药的研发提供参考依据。Resveratrol is a natural compound that belongs to the non-flavonoid group of polyphenol compounds found in a variety of plant bodies.Modern research has found that resveratrol has pharmacological activities such as anti-inflammatory,antioxidant,antitumor,and regulation of metabolism and organism immunity.Resveratrol has inhibitory effects on colon cancer,pancreatic cancer,ovarian cancer,breast cancer and many other tumor cells,and its anti-tumor effects are gradually becoming a hot spot for research.Resveratrol can exert anti-tumor activity by inhibiting the proliferation of tumor cells,inducing apoptosis,inhibiting tumor cell invasion and metastasis,regulating the body’s immune function,and acting directly on the relevant targets.By reviewing the domestic and international literature in recent years,the role and mechanism of resveratrol in different tumor cells were reviewed in order to provide a reference basis for the development of new anti-tumor drugs.

关 键 词：白藜芦醇 抗肿瘤 抑制癌细胞生长 诱导癌细胞凋亡 增强免疫细胞活性 

分 类 号：R285.5[医药卫生—中药学]