柳氮磺吡啶的药动学及其临床应用  

Pharmacokinetics of Sulfasalazine and Its Clinical Application

作　　者：蔡杰 王广飞[1] 陈阳[1] 卢金淼[1] 张晓波 李智平[1] CAI Jie;WANG Guangfei;CHEN Yang;LU Jinmiao;ZHANG Xiaobo;LI Zhiping(Dept.of Clinical Pharmacy,National Children’s Medical Center/Children’s Hospital of Fudan University,Shanghai 201102,China;Dept.of Respiratory,National Children’s Medical Center/Children’s Hospital of Fudan University,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心/复旦大学附属儿科医院临床药学部,上海201102 [2]国家儿童医学中心/复旦大学附属儿科医院呼吸科,上海201102

出　　处：《中国医院用药评价与分析》2023年第4期506-509,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：上海市科学技术委员会科研项目(No.19DZ1910703)。

摘　　要：柳氮磺吡啶(SSZ)是一种由磺胺吡啶(SP)和5-氨基水杨酸(5-ASA)通过偶氮键链接而成的前体药物,口服后在结肠部位被肠道菌群再次分解为SP和5-ASA。在体内,SSZ母体及其代谢产物SP和5-ASA均具有药理活性,并通过不同的作用机制主要表现出抗菌、抗炎及免疫抑制作用。目前,SSZ在临床上主要被用于类风湿关节炎、炎性肠病和皮肤病的治疗。并且已有多项研究结果指出,其在多种肿瘤的治疗中表现出良好的潜力。虽然SSZ已在临床上得到了广泛的应用,但其不良反应仍然不容小视。SSZ最常见的不良反应为消化系统不良反应,此外还可能发生严重的血液系统不良反应。本文总结已有研究中SSZ的药动学、临床应用及不良反应的相关报道,以期为其得到更好的临床应用提供一定的参考意见。Sulfasalazine(SSZ)is a kind of precursor drug consisting of sulfapyridine(SP)and 5-aminosalicylic acid(5-ASA)linked by an azoic bond,which can be broken down again by intestinal flora into SP and 5-ASA after oral administration.In vivo,the SSZ parent and its metabolites SP and 5-ASA are pharmacologically active,and mainly presenting antibacterial,anti-inflammatory and immunosuppressive effects through different mechanisms.Currently,SSZ is mainly used in the clinical treatment of rheumatoid arthritis,inflammatory bowel disease and skin diseases.Results of several studies have shown that SSZ has good potential in the treatment of various tumors.Although SSZ has been widely used in clinical practice,yet its adverse drug reactions should not be underestimated.The most common adverse drug reactions of SSZ are digestive system adverse reaction,and serious hematological system adverse reaction may also occur.This paper summarizes the pharmacokinetics,clinical application and adverse drug reactions of SSZ in the existed studies,in order to provide some reference for its better clinical application.

关 键 词：柳氮磺吡啶 药动学 类风湿关节炎 炎性肠病 

分 类 号：R978.2[医药卫生—药品]