DDB2单核苷酸多态位点rs830083CG变异与非吸烟人群肺癌易感性的关系  

Relationship between rs830083CG mutation of DDB2 single nucleotide polymorphism locus and lung can⁃cer susceptibility of non⁃smokers

作　　者：段东奎[1] 王铮[1] 王新[1] 张耕瑞 DUAN Dongkui;WANG Zheng;WANG Xin;ZHANG Gengrui(Department of Thoracic Surgery,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院胸外科,河南南阳473000

出　　处：《实用医学杂志》2023年第7期855-859,共5页The Journal of Practical Medicine

基　　金：2020年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20200907)。

摘　　要：目的分析DNA损伤结合蛋白2(DDB2)单核苷酸多态位点rs830083CG变异与非吸烟人群肺癌易感性的关系。方法选择2020年3月至2021年3月收治的158例非吸烟肺癌患者为研究组,选择同期100例体检健康人群为对照组,检测DDB2基因单核苷酸多态性(SNP)位点rs830083多态性,采用非条件logistic回归模型分析DDB2基因多态性与非吸烟人群肺癌易感性的关系,并评估环境暴露因素与DDB2基因rs830083位点多态性的交互作用。结果研究组和对照组DDB2基因rs830083位点CC、CG、GG基因型频率分别为36.08%、52.53%、11.39%和53.00%、39.00%、8.00%;C、G等位基因频率分别为62.34%、37.66%和75.50%、27.50%,差异均有统计学意义(P<0.05)。两组DDB2基因rs830083位点基因型分布,在显性模式下,差异有统计学意义(P<0.05),在隐性模式下差异则无统计学意义(P>0.05)。与CC基因型比较,CG+GG基因型与非吸烟人群肺癌易感性有关。相比于rs830083位点CC基因型非暴露个体,携带CG+GG基因型且暴露的个体肺癌患病风险增加4.444倍,被动吸烟暴露与DDB2基因rs830083位点多态性存在交互作用。结论DDB2单核苷酸多态位点rs830083CG变异与非吸烟人群肺癌易感性有关,携带G等位基因可能增加非吸烟人群肺癌患病风险,其与被动吸烟暴露存在交互作用。Objective To analyze the relationship between rs830083CG mutation of damage specific DNA binding protein 2(DDB2)single nucleotide polymorphism locus and lung cancer susceptibility of non⁃smokers.Methods One hundred and fifty⁃eight patients with non⁃smoking lung cancer admitted to a hospital in Nanyang City from March 2020 to March 2021 were selected as the study group,and another 100 healthy people in the same period were selected as the control group.The single nucleotide polymorphism(SNP)of DDB2 gene rs830083 poly⁃morphism from both groups was detected,and the relationship between DDB2 gene polymorphism and the suscepti⁃bility of non⁃smoking people to lung cancer was analyzed by unconditional logistic regression model.The interaction between environmental exposure factors and the rs830083 polymorphism of DDB2 gene was evaluated.Results The genotype frequencies of CC,CG and GG at rs830083 of DDB2 gene in the study group and control group were 36.08%,52.53%,11.39%and 53.00%,39.00%and 8.00%,respectively.The frequencies of C and G alleles were 62.34%,37.66%and 75.50%,27.50%respectively,with significant differences between the two groups(P<0.05).The genotype distribution of rs830083 of DDB2 gene was statistically significantly different between the two groups in dominant mode(P<0.05),but not in recessive mode(P>0.05).Compared with the CC geno⁃type,the CG+GG genotype was associated with the lung cancer susceptibility of non⁃smokers.Passive smoking ex⁃posure increased the risk of lung cancer(adjusted OR=2.411,95%CI:1.149⁃5.061,P<0.05).Compared with non⁃exposed individuals with CC genotype at rs830083,the risk of lung cancer in the exposed individuals with CG+GG genotype was increased by 4.444 times(95%CI:1.212⁃16.294,P<0.05).There was an interaction effect be⁃tween passive smoking exposure and DDB2 gene rs830083 locus polymorphism(P<0.05).Conclusion The rs830083CG mutation of DDB2 single nucleotide polymorphism locus is related to the susceptibility of lung cancer in non⁃smokers.Non⁃smoke

关 键 词：DNA损伤结合蛋白2 基因多态性 非吸烟者 肺癌 易感性 

分 类 号：R655.3[医药卫生—外科学]