南方汉族人群ABCG2 rs2231142和SLC2A9 rs3733591单核苷酸多态性与高尿酸血症及心血管危险因素的相关性  

Association of ABCG2 rs 2231142 and SLC2A9rs 3733591 gene polymorphisms with hyperuricemia in Southern Han population

作　　者：王贤方 刘志东[1] 张园 黄常镜 张海飞 余丽琼 钟炜[1] WANG Xianfang;LIU Zhidong;ZHANG Yuan;HUANG Changjing;ZHANG Haifei;YU Liqiong;ZHONG Wei(Department of Cardiovascular Medicine,Meizhou People′s Hospital,Meizhou 514031,China;不详)

机构地区：[1]梅州市人民医院心血管内科,广东梅州514031 [2]广州医科大学附属第三医院老年医学科,广州510510

出　　处：《实用医学杂志》2023年第7期875-880,共6页The Journal of Practical Medicine

基　　金：梅州市人民医院科研培育项目(编号:PY-C2020034)。

摘　　要：目的探讨ABCG2 rs2231142和SLC2A9 rs3733591与高尿酸血症(HUA)及心血管危险因素的相关性。方法选取两家三甲医院收治的HUA患者(HUA组)和健康人群(对照组),检测各项指标指标、提取DNA并检测各组基因型。结果HUA组的BMI、sCr、TG和LDL水平高于对照组(P<0.05)。HUA组的ABCG2等位基因频率高于对照组;UA与这2个SNP密切相关(P<0.05);但是ABCG2 rs2231142与心血管危险因素也存在相关性(P<0.05),且有性别差异。结论ABCG2 rs2231142和SLC2A9rs3733591单核苷酸多态性与高尿酸血症易感性相关,遗传风险变异和心血管危险因素对sUA水平存在联合影响。Objective To investigate the association between ABCG2 rs2231142,SLC2A9 rs3733591,hyperuricemia(HUA)and cardiovascular risk factors.Methods HUA patients and healthy people were admitted to two hospitals.All patients were selected to detect various index indexes,extract DNA and detect genotypes.Results The levels of BMI,sCr,TG and LDL in HUA group were higher than those in normal group(P<0.05).The frequency of ABCG2 alleles was higher in the HUA group than in the control group;UA was strongly associated with these two SNPs(P<0.05);however,ABCG2 rs 2231142 was also associated with cardiovascular risk factors(P<0.05),and there were gender differences.Conclusion ABCG2 rs2231142 and SLC2A9rs 3733591 single nucleotide polymorphisms are associated with susceptibility to hyperuricemia,and cardiovascular risk factors have a combined effect on sUA levels.

关 键 词：高尿酸血症 单核苷酸多态性 危险因素 

分 类 号：R589.7[医药卫生—内分泌]