老年原发性干燥综合征并发颈动脉粥样硬化风险:剂量反应相关性  

The risk of primary sjogren's syndrome complicated by carotid atherosclerosis:dose-response correlation

作　　者：张艺文 秦地茂 杨晓倩 秦莉 罗强 汪汉 ZHANG Yi-Wen;QIN Di-Mao;YANG Xiao-Qian(Dapartment of Cardiology,Affiliated Hospital of Southwest Jiaotong University&the Third People's Hospital of Chengdu&Chengdu Institute of Cardiovascular Disease,Chengdu 610031,Sichuan,China)

机构地区：[1]西南交通大学附属医院、成都市第三人民医院心内科、成都市心血管病研究所,四川成都610031

出　　处：《中国老年学杂志》2023年第9期2049-2052,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(81300243);四川省科技厅面上项目(2019YJ0634);四川省医学科研青年创新课题(Q14013);四川省卫计委普及应用项目(16PJ042)。

摘　　要：目的探讨老年原发性干燥综合征(pSS)患者合并颈动脉粥样硬化的现况及相关因素。方法回顾性分析109例老年pSS患者与同期109例性别、年龄匹配的健康人群的一般临床资料、实验室检查及颈动脉超声结果。使用多因素Logistic回归分析探究pSS患者合并颈动脉粥样硬化的相关因素,使用限制性立方样条曲线描述二者间的剂量-反应关系。结果与对照组相比,pSS患者合并斑块的患病率显著更高,内膜厚度显著增加(P<0.05)。多因素分析结果显示收缩压是老年pSS患者合并颈动脉斑块的相关因素(P<0.05),剂量-反应曲线显示收缩压与pSS患者发生颈动脉斑块风险之间存在线性关联(P<0.05)。结论老年pSS患者颈动脉粥样硬化风险增加,收缩压水平与老年pSS患者颈动脉斑块形成相关,控制血压,关注老年pSS患者的颈动脉粥样硬化风险,对降低其不良心血管事件的发生率十分重要。Objective To investigate the current status and related factors of carotid atherosclerosis in elderly patients with primary sjogren's syndrome(pSS).Methods The general clinical data,laboratory examinations and carotid ultrasound results of 109 elderly patients with pSS and 109 gender and age-matched healthy people in the same period were retrospectively analyzed.Multivariate Logistic regression analysis was used to explore the related factors of pSS patients with carotid atherosclerosis,and the restricted cubic spline curve was used to describe the dose-response correlation between them.Results Compared with the control group,patients with pSS and carotid plaque had a significantly higher prevalence and intimal thickness was significantly increased(P<0.05).The results of multivariate analysis showed that systolic blood pressure was related to carotid plaque formation in elderly patients with pSS(P<0.05).The dose-response curve showed a linear correlation between systolic blood pressure and the risk of carotid plaque in pSS patients(P<0.05).Conclusions The risk of carotid atherosclerosis in elderly patients with pSS is increased.The level of systolic blood pressure is related to carotid plaque formation in elderly patients with pSS.It is important to control blood pressure and pay attention to the risk of carotid atherosclerosis in elderly patients with pSS to reduce the incidence of adverse cardiovascular events.

关 键 词：原发性干燥综合征 颈动脉粥样硬化 剂量反应关系 

分 类 号：R593.2[医药卫生—内科学]