二茂铁基三烯酮类姜黄素类似物的合成、晶体结构及电化学性质  

Syntheses,Crystal Structure and Electrochemical Properties of Ferrocene-Based Trienone Curcumin Analogues

作　　者：卢博 陈芳圆 任淑慧 万屏南[1] 李靖聪 欧阳雯婷 林艳[1] 崔汉峰[1] Lu Bo;Chen Fangyuan;Ren Shuhui;Wan Pingnan;Li Jingcong;Ouyang Wenting;Lin Yan;Cui Hanfeng(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang,330004;Department of Chinese Medicine,Jiangxi Pharmaceutical School,Nanchang,330200)

机构地区：[1]江西中医药大学药学院,南昌330004 [2]江西省医药学校中医药系,南昌330200

出　　处：《化学通报》2023年第4期491-494,504,共5页Chemistry

基　　金：国家自然科学基金项目(82160729);江西省教育厅科学技术研究项目(GJJ201226,GJJ190668,GJJ211234);江西省中医药管理局科技计划项目(2022A379)资助。

摘　　要：以不同取代基的肉桂醛和二茂铁为起始原料,经Vilsmeier-Haack甲酰化反应、Claisen-Schmidt等反应合成5种新型二茂铁基三烯酮类姜黄素类似物,其结构经^(1)H NMR、^(13)C NMR和HRMS(ESI-TOF)表征,并用X-ray单晶衍射确定了5d的晶体结构,其构型为反式构型,电化学研究表明化合物5a具有较高氧化还原活性。Five new ferrocene-based trienone curcumin analogues were synthesized in three steps by Vilsmeier-Haack formylation and Claisen-Schmidt reactions using ferrocene as starting material.Their structures were characterized by ^(1)H NMR,^(13)C NMR and HRMS(ESI-TOF),and the crystal structure of 5d was determined by X-ray single-crystal diffraction,and the conformation was trans.Electrochemical studies showed that compound 5a has high redox activity.

关 键 词：二茂铁 三烯酮 合成 晶体结构 电化学性质 

分 类 号：O629[理学—有机化学] O76[理学—化学]