4种双香豆素类化合物对赤子爱胜蚓的安全性评价  

Safety evaluation of four biscoumarin derivatives on Eisenia foetida

作　　者：范继文 苏来 赵娜娜[1] 张乐 路伟[1] FAN Ji-wen;SU Lai;ZHAO Na-na;ZHANG Le;LU Wei(College of Agriculture/Engineering Research Centre of Cotton,Ministry of Edecation/Key Laboratory of Prevention and Control of Invasive Alien Species in Agriculture&Forestry of the North-western Desert Oasis(Co-construction by Ministry and Province),Ministry of Agriculture and Rural Affairs,Xinjiang Agricultural University,Ürümqi 830052,China;Guorino Drug Safety Evaluation Research Co.,Ltd.,Xi'an 710000,China)

机构地区：[1]新疆农业大学农学院/棉花教育部工程研究中心/农业农村部西北荒漠绿洲农林外来入侵生物防控重点实验室,乌鲁木齐830052 [2]国睿一诺药物安全评价研究有限公司,西安710000

出　　处：《农药》2023年第4期266-271,287,共7页Agrochemicals

基　　金：天山创新团队计划项目(2020D14001)。

摘　　要：[目的]评价4种双香豆素类化合物(biscoumarin,BCM)对赤子爱胜蚓(Eisenia foetida)的安全性。[方法]采用人工土壤法分别测定4种双香豆素类化合物对赤子爱胜蚓的急性毒性与繁殖毒性。[结果]BCM4、BCM7、BCM8、BCM12对赤子爱胜蚓14 d的急性毒性LC_(50)分别为514.90、566.87、197.93、210.88 mg/kg干土,4种BCM对赤子爱胜蚓均属于低毒农药,对环境安全;BCM4、BCM7、BCM8、BCM12在4个亚致死浓度作用下对赤子爱胜蚓体质量、孵化幼蚓数、平均蚓茧孵化数和产茧数的抑制作用与CK组有着显著性差异(P<0.05)且小于对照药剂醚菌酯、多菌灵对赤子爱胜蚓繁殖的抑制作用。[结论]BCM4、7、8、12相比化学农药醚菌酯和多菌灵对赤子爱胜蚓更加安全,对赤子爱胜蚓为低毒。[Aims]To evaluate the safety of 4 biscoumarin compounds(BCMs)on Eisenia foetida.[Methods]The acute toxicity and reproductive toxicity of 4 BCMs to E.foetida were determined by artificial soil method.[Results]The acute toxicity(14 d)LC_(50) of BCM4,BCM7,BCM8 and BCM12 to E.foetida were 514.90,566.87,197.93 and 210.88 mg/kg dry soil,respectively.The 4 BCMs were all low toxic to E.foetida and were safe to the environment.The inhibitory effects of BCM4,BCM7,BCM8 and BCM12 on the body weight,number of larvae,average of hatched cocoons and number of laid cocoons under 4 sublethal concentrations were significantly different from those in the CK group(P<0.05),and showed less inhibitory effect than kresoxim-methyl and carbendazimon the reproduction of E.foetida.[Conclusions]Compared with chemical pesticides kresoxim-methyl and carbendazim,BCM4,7,8 and 12 are safer and less toxic to E.foetida.

关 键 词：双香豆素类化合物 赤子爱胜蚓 繁殖毒性 急性毒性 人工土壤法 

分 类 号：TQ450.2[化学工程—农药化工]