生物材料促进创面血管化的研究进展  

Research progress of biomaterials in promoting wound vascularization

作　　者：陈良龙 于盛祥 马军[1] 高艳彬[1] 杨磊[1] Chen Lianglong;Yu Shengxiang;Ma Jun;Gao Yanbin;Yang Lei(Department of Burns,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院烧伤科,广州510515

出　　处：《中华烧伤与创面修复杂志》2023年第4期381-385,共5页Chinese Journal of Burns And Wounds

基　　金：广东省自然科学基金(2020A151501108);广东省重点领域研发计划项目(2020B1111150001);广东省省级科技计划项目(2018KJYZ005);西藏自治区自然科学基金(XZ2017ZR-ZY021)。

摘　　要：快速、良好的促血管化目前仍然是创面修复生物材料研发面临的巨大挑战。目前研究表明创面血管化与生物材料的孔隙、成分、通道等密切相关。近年来,虽然新型医用功能材料的研发取得了突飞猛进的发展,其在重建皮肤屏障功能、调控创面微环境、抗菌消炎等方面取得可喜成果,但仍未解决创面快速血管化难题。该文介绍了创面血管化进程、生物材料促进创面血管化的策略、基于三维打印技术构建促进创面血管化的生物材料、纳米技术对创面血管化的影响,以期为未来快速血管化创面修复材料的研发提供新的启示。Promoting rapid and good vascularization is still a great challenge for the research and development of biomaterials for wound repair.Current studies have shown that wound vascularization is closely related to the pores,components,and channels of biomaterials.Although the research and development of new medical functional materials have made rapid progress in recent years,and gratifying achievements have been made in the reconstruction of skin barrier function,regulation of wound microenvironment,and antibacterial and anti-inflammatory effects,etc.,the problem of rapid wound vascularization has not been solved.This paper introduces the process of wound vascularization,the strategy of biomaterials promoting wound vascularization,the construction of biomaterials promoting wound vascularization based on three-dimensional printing technology,and the influence of nanotechnology on wound vascularization,in order to provide new enlightenment for research and development of wound repair materials with rapid vascularization in the future.

关 键 词：生物相容性材料 新生血管化 生理性 打印 三维 创面修复 纳米材料 

分 类 号：R318.08[医药卫生—生物医学工程]