壳聚糖基创面敷料在创面愈合中的作用及其机制研究进展  

Research advances on the role and mechanism of chitosan-based wound dressing in wound healing

作　　者：胡宗浩 阿依谢姆·玉苏甫 曲悦 谢金洪 殷丽华[1] Hu Zonghao;Ayixiemu·Yu sufu;Qu Yue;Xie Jinhong;Yin Lihua(Department of Oral Implant,School/Hospital of Stomatology,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学口腔医学院(口腔医院)口腔种植科,兰州730000

出　　处：《中华烧伤与创面修复杂志》2023年第4期386-390,共5页Chinese Journal of Burns And Wounds

基　　金：甘肃省科技计划国际合作专项(18YF1WA116);甘肃省省级引导科技创新发展竞争性项目专项资金(2018ZX-10);兰州市人才创新创业项目(2017-RC-31)。

摘　　要：皮肤是维持机体内环境稳定及抵御外环境有害因素的第1道屏障,且易因外界各种因素受到损伤。当全层皮肤缺损达到一定程度时,皮肤很难进行自我修复,需要创面敷料来促进创面愈合。长期以来,寻找一种能促进创面愈合的理想敷料一直是研究热点。壳聚糖是一种独特的生物多糖聚合物,具有良好的生物相容性、生物降解性、抗菌活性及热稳定性等,在创面敷料的研发与应用方面具有巨大潜力。该文在介绍壳聚糖性质的基础上,综述了壳聚糖基创面敷料在创面愈合中的作用和机制,从壳聚糖的止血作用、抗菌作用、递送作用和促组织再生作用等方面进行了总结,旨在为未来新型壳聚糖基创面敷料的研发提供一定的参考。The skin is the first barrier to maintain the stability of internal environment of the body and resist harmful factors of external environment,and is easily damaged because of various external factors.When full-thickness skin defects reach a certain level,it is difficult for the skin to repair itself,so wound dressings are needed to promote wound healing.Seeking an ideal dressing that can promote wound healing has long been a hot research topic.Chitosan is a unique biopolysaccharide polymer with good biocompatibility,biodegradability,antibacterial activity,and thermal stability,which has great potential in the development and application of wound dressings.Based on the introduction of properties of chitosan,this article reviews the role and mechanism of chitosan-based wound dressings in wound healing,and summarizes the hemostatic effect,antibacterial effect,delivery effect,and tissue regeneration promotion effect of chitosan,aiming to provide a certain reference for the research and development of new chitosan-based wound dressings in the future.

关 键 词：壳聚糖 生物敷料 组织工程 创面愈合 作用机制 

分 类 号：R641[医药卫生—外科学]