补体系统激活在烧伤后免疫中的作用研究进展  

Research advances on the role of complement system activation in post-burn immunity

作　　者：黄圣宇 朱峰 郭光华[1] Huang Shengyu;Zhu Feng;Guo Guanghua(Medical Center of Burn Plastic and Wound Repair,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Burn Department,the First Affiliated Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]南昌大学第一附属医院烧伤整形与创面修复医学中心,南昌330006 [2]海军军医大学第一附属医院烧伤科,上海200433

出　　处：《中华烧伤与创面修复杂志》2023年第4期396-400,共5页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2019YFA0110601);国家自然科学基金地区科学基金项目(82160376,81760342,81960352);江西省科技厅重点研发计划重点项目(20171ACG70004);江西省青年科学基金项目(20192BAB215029)。

摘　　要：免疫激活是烧伤后继发性损伤的重要因素之一,也是抗感染过程中主要的机体反应。补体系统作为先天性免疫反应中的重要部分,能够在烧伤后诱导免疫细胞激活,促进炎症与介导免疫屏障的破坏,甚至与凝血级联发生复杂交联。该文从先天性免疫、获得性免疫以及补体系统与凝血级联交联的角度,综述补体系统激活在烧伤后免疫中的作用及其在临床中转化的可能性。Immune activation is one of the major factors of secondary injury post burn,and is the main organismal response in the anti-infection process.As an important part of the innate immune response,the complement system is able to induce the activation of immune cells after burns,promote inflammation and mediate the breakdown of the immune barrier,and even engage in complex cross-linking with the coagulation cascade.This article reviews the role of complement system activation in post-burn immunity and its possibility of clinical translation from the perspectives of innate immunity,acquired immunity,and cross-linking of the complement system with the coagulation cascade.

关 键 词：烧伤 补体激活 免疫 凝血级联 

分 类 号：R644[医药卫生—外科学]