药用植物裂环烯醚萜苷类化合物生物合成途径关键酶基因研究进展  

A Research Progress of Key Enzyme Genes in Biosynthetic Pathway of Schizoiridoid Glycosides in Medicinal Plants

作　　者：戴欣怡 朱锦峰 韦善屹 朱雄智 李竞舸 刘越[1,2] DAI Xinyi;ZHU Jinfeng;WEI Shanyi;ZHU Xiongzhi;LI Jingge;LIU Yue(Key Laboratory of Ecology and Environment in Minority Areas,National Ethnic Affairs Commission,Beijing 100081,China;College of Life and Environmental Sciences,Minzu University of China,Beijing 100081,China)

机构地区：[1]民族地区生态环境国家民委重点实验室[中央民族大学],北京100081 [2]中央民族大学生命与环境科学学院,北京100081

出　　处：《西北植物学报》2023年第3期527-538,共12页Acta Botanica Boreali-Occidentalia Sinica

基　　金：国家重点研发计划“政府间国际科技创新合作重点专项”(2022YFE0119300);国家自然科学基金(81274185,81373765);国家民委中青年英才项目(2016-3-01);中央民族大学硕士研究生自主科研项目(SZKY2022042);中央民族大学一流大学一流学科建设;中央民族大学创新项目(BEIJ2020110021,URTP2020110065,BEIJ2021110107,BEIJ2021110128)。

摘　　要：裂环烯醚萜苷类化合物是植物体内产生的具有保肝、消炎、降血糖血脂等多重生物活性的次级代谢产物,在临床上应用广泛。该文依据近年来国内外有关裂环烯醚萜苷类化合物生物合成途径及关键酶基因的挖掘与调控机理研究进展,主要对药用植物裂环烯醚萜苷类化合物生物合成途径、关键酶(GPPS、GES、G10H、8HGO、IS、IO、7DLGT、DL7H、LAMT、SLS)与编码基因的研究进展进行综述,为进一步阐明其生物合成途径机制与关键酶调控作用、提高有效活性成分积累、减缓药用植物野生资源紧张等问题提供参考。Schizoiridoid glycosides are secondary metabolites produced in plants with multiple biological activities such as liver protection,anti-inflammatory,hypoglycemic and blood lipids,and are widely used in clinical practice.Based on the research progress on the biosynthesis pathway of schizoiridoid glycosides and the mining and regulation mechanism of key enzyme genes at home and abroad in recent years,this paper mainly reviews the research progress of the biosynthesis pathway of schizoiridoid glycosides in medicinal plants,key enzymes(GPPS,GES,G10H,8HGO,IS,IO,7DLGT,DL7H,LAMT,SLS)and coding genes.It provides a basis for further elucidating the mechanism of its biosynthesis pathway and the regulation of key enzymes,improving the accumulation of effective active ingredients,and easing the tension of wild resources of medicinal plants.

关 键 词：裂环烯醚萜苷 药用植物 关键酶基因 生物合成途径 

分 类 号：Q949.95[生物学—植物学]