虎杖利胆退黄药理作用机制的研究进展  

Research progress on pharmacological effect and mechanism of Polygonum cuspidatum in normalizing the gallbladder to treat jaundice

作　　者：丁楠 张天娇 李雪[1] 陈潮[1] 杨铭[1] Nan DING;Tian-Jiao ZHANG;Xue LI;Chao CHEN;Ming YANG(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《药物流行病学杂志》2023年第3期323-331,共9页Chinese Journal of Pharmacoepidemiology

基　　金：国家中医药管理局中医药循证能力建设项目(1749);龙华医院第二批科研人才培养计划(RC-2020-02-04);第四批“龙医学者”育苗计划(YM2021016);国家十三五重大新药创制科技重大专项(2017ZX09304001);上海市自然科学基金项目(22ZR1462100)。

摘　　要：虎杖已被证实具有利胆退黄的药理作用,且在临床上被用于治疗胆汁淤积性肝病和黄疸型肝炎,探究虎杖利胆退黄药理作用机制对拓展其在临床上的应用以及开展后续研究都至关重要。目前对于虎杖利胆退黄的药理机制已有部分研究,主要是从胆汁酸代谢和胆红素代谢这两条代谢通路作为切入点进行。本文通过调研有关文献,从虎杖的活性成分和复方制剂两个层面出发,发现目前的研究多聚焦于影响体内胆汁酸和胆红素稳态的酶或受法尼醇X受体调控的转运蛋白上,另外也有研究发现炎症和氧化应激也与胆汁淤积有关,所以从这些角度综述了虎杖利胆退黄药理作用机制研究进展,以期为后续虎杖进一步研究奠定基础。Polygonum cuspidatum has been proved to have the pharmacological effect of normalizing the gallbladder to treat jaundice,and has been used in clinical treatment of cholestatic liver disease and icteric hepatitis.Therefore,it is important to explore its pharmacological mechanism of normalizing the gallbladder to treat jaundice to expand its clinical application and carry out further research on Polygonum cuspidatum.At present,there have been some studies on the pharmacological mechanism of Polygonum cuspidatum,mainly from the two metabolic pathways of bile acid metabolism and bilirubin metabolism as entry points for in-depth research.In this paper,based on the research of relevant literature,starting from the active components and compound preparations of Polygonum cuspidatum,it is found that the current research mainly focuses on the enzymes that affect the homeostasis of bile acid and bilirubin in the body or the transporters regulated by the farnesoid X receptor.In addition,there are also studies that found that inflammation and oxidative stress are also related to cholestasis.Therefore,the research progress of the pharmacological action mechanism of Polygonum cuspidatum for normalizing the gallbladder to treat jaundice is reviewed from these perspectives.It is expected to lay a foundation for further study of Polygonum cuspidatum.

关 键 词：虎杖 利胆退黄 中药 药理机制 研究进展 

分 类 号：R285[医药卫生—中药学]