自身抗体检测的规范化及实践  

Current practices in the harmonisation of autoantibodies test

作　　者：周仁芳 何敏 杨滨[3] 李晞[4] 胡朝军 Zhou Renfang;He Min;Yang Bin;Li Xi;Hu Chaojun(Department of Laboratory Medicine,Affiliated Wenling Hospital of Wenzhou Medical University,Taizhou 317500,China;Department of Laboratory Medicine,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China;Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Laboratory Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases,Ministry of Science&Technology,State Key Laboratory of Complex Severe and Rare Diseases,Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education,Beijing 100730,China)

机构地区：[1]温州医科大学附属温岭医院检验科,台州317500 [2]广州中医药大学第二附属医院,广东省中医院检验医学部,广州510120 [3]四川大学华西医院实验医学科,成都610041 [4]广西医科大学第一附属医院检验科,南宁530021 [5]中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,国家皮肤与免疫疾病临床医学研究中心,疑难重症及罕见病国家重点实验室,风湿免疫病学教育部重点实验室,北京100730

出　　处：《中华内科杂志》2023年第4期356-362,共7页Chinese Journal of Internal Medicine

基　　金：浙江省医药卫生科技计划项目(2022KY1413);国家重点研发计划项目(2019YFC0840603)。

摘　　要：随着自身抗体检测的临床推广应用,对自身抗体检测的标准化和规范化显得尤为重要。由于自身抗体检测的复杂性和特殊性,标准化往往难以完全实现并遇到诸多挑战,而规范化切实可行且不断被重视,但其涉及到自身抗体检测的各个过程、多个方面。鉴于此,结合国内外近年来发布的相关自身抗体检测的临床应用共识及其实践,探讨自身抗体检测的规范化。Standardisation and harmonisation of the detection of autoantibodies is important for the clinical application of autoantibodies.However,achieving complete standardisation is difficult and involves several challenges due to the complexity and particularity of autoantibody detection.Harmonisation is feasible and valued,but it involves all aspects and processes of autoantibody detection.Based on the consensus and practice of the clinical application of autoantibody detection in recent years,we discuss harmonisation in this review.

关 键 词：自身抗体 标准化 规范化 

分 类 号：R446.6[医药卫生—诊断学]