糖尿病视网膜神经变性早期检测及神经保护疗法的研究进展  

Research progress on early detection and neuroprotective therapy of diabetic retinal neurodegeneration

作　　者：卢泽彬 叶亲颖 Lu Zebin;Ye Qinying(Guangdong Medical University,Zhanjiang,Guangdong,524000,China;The Second Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,524000,China)

机构地区：[1]广东医科大学,广东湛江524000 [2]广东医科大学附属第二医院,广东湛江524000

出　　处：《齐齐哈尔医学院学报》2023年第7期658-663,共6页Journal of Qiqihar Medical University

摘　　要：糖尿病视网膜神经变性(DRN)是慢性高血糖刺激引起的以视网膜神经血管单元(RNVU)功能障碍为主要表现的视网膜神经组织退行性病变,以反应性胶质增生及视网膜神经节细胞凋亡为关键特征。临床中大多数糖尿病患者在发生糖尿病视网膜病变(DR)之前,已可检测出DRN的存在,但目前DR的防治重心仍处于应对其微血管病变阶段。早期诊治DRN或将更好地保护糖尿病患者视功能,降低其进展为DR的风险。Diabetic retinal neurodegeneration(DRN)is a degenerative lesion of retinal nerve tissue caused by chronic hyperglycemic stimulation with the main manifestation of the retinal neurovascular unit(RNVU)dysfunction.Reactive gliosis and retinal ganglion cell apoptosis are its key features.The presence of DRN can be detected before the development of diabetic retinopathy(DR)in most diabetic patients clinically.But the focus of DR prevention and treatment is still at the stage of dealing with its microangiopathy.Early diagnosis and treatment of DRN may better protect the visual function of diabetic patients and reduce their risk of progression to DR.

关 键 词：糖尿病 糖尿病视网膜神经变性 神经血管单元 神经保护 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]