吴门调脂颗粒治疗肥胖2型糖尿病合并代谢性脂肪性肝病疗效观察  

Clinical Observation on Wumen Fat-regulating Granules in the Treatment of Obesity Type Two Diabetes Mellitus and Metabolic Associated Fatty Liver Disease

作　　者：殷美琦[1] 金丽娟[1] 刘元君[1] 黄菲[1] YIN Meiqi;JIN Lijuan;LIU Yuanjun;HUANG Fei(Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215009

出　　处：《西部中医药》2023年第4期97-100,共4页Western Journal of Traditional Chinese Medicine

基　　金：苏州市卫健委科教兴卫项目(KJXW2017044);苏州市科技局项目(SYSD2019148);苏州市中西医结合学会项目(SYSD2019214);苏州市临床医学专家团队引进项目(SZYJTD201718)。

摘　　要：目的:观察吴门医派调脂颗粒治疗肥胖2型糖尿病(type 2 diabetes mellitus,T2DM)合并代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)的临床疗效及对血清趋化素(Chemerin)水平的影响。方法:纳入55例肥胖T2DM合并MAFLD患者,随机分为观察组(28例)和对照组(27例)。对照组采用常规西医治疗,观察组在此基础上加用调脂颗粒治疗。治疗12周后,观察两组体质指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glucosylated hemoglobin,HbA1c)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance,HOMA-IR)、血脂、肝功能指标及血清Chemerin水平。结果:治疗12周后,观察组BMI、FPG、HbA1c、谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)、血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)均较治疗前显著降低(P<0.01),血清Chemerin、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素8(interleukin-8,IL-8)水平亦较治疗前显著降低(P<0.01)。对照组BMI、FPG、HbA1c、ALT、AST、TC、TG、IL-8较治疗前下降(P<0.05),血清Chemerin、TNF-α水平较治疗前显著下降(P<0.01)。治疗后,观察组与对照组相比,BMI、FPG、TC、LDL-C、血清Chemerin、TNF-α、IL-8水平更低(P<0.05)。结论:吴门调脂颗粒治疗肥胖T2DM合并MAFLD能够减轻体质量、改善糖脂代谢,降低血清Chemerin水平,减轻炎症状态,提高临床疗效。Objective:To observe clinical efficacy of Wumen fat-regulating granules in treating obesity type two diabetes mellitus(T2DM)and MAFLD,and its influence on the level of Chemerin.Methods:fifty-five patients were included and randomized into the observation group(28 cases)and the control group(27 cases).The control group adopted conventional therapy of Western medicine,and the observation group took fat-regulating granules orally.After 12 weeks of the treatment,to observe BMI,FPG,HbA1c,HOMA-IR,blood lipid,the indexes of liver function and the levels of serum Chemerin between both groups.Results:After 12 weeks of the treatment,BMI,FPG,HbA1c,ALT,AST,TC,TG and LDL-C of the observation group lowered than before the treatment signi-ficantly(P<0.01),the levels of serum Chemerin,TNF-αand IL-8 reduced compared with before the treatment noticeably(P<0.01).BMI,FPG,HbA1c,ALT,AST,TC,TG and IL-8 of the control group lowered than before the treatment(P<0.05),the levels of serum Chemerin and TNF-αlowered remarkably than before the treatment(P<0.01).After the treatment,BMI,FPG,TC,LDL-C,the levels of serum Chemerin,TNF-αand IL-8 were lower when the observation group was compared with the control group(P<0.05).Conclusion:Wumen fatregulating granules of in the treatment of obesity T2DM and MAFLD could lose weight,improve glucose and lipid metabolism,reduce the levels of serum Chemerin,relieve inflammatory state and raise clinical effects.

关 键 词：糖尿病 2型 肥胖 调脂颗粒 代谢相关脂肪性肝病 吴门医派 

分 类 号：R587.2[医药卫生—内分泌]