亚胺培南/西司他丁钠致白细胞及血小板减少1例  

Leucopenia and Thrombocytopenia Induced by Imipenem/Cilastatin Sodium:One Case Report

作　　者：吴丽莎 吴婵娟 朱新华 林伟豪 WU Li-sha;WU Chan-juan;ZHU Xin-hua;LIN Wei-hao(Dept.of Pharmacy,Pingshan People′s Hospital,Shenzhen 518118,China)

机构地区：[1]深圳市坪山区人民医院药剂科,广东深圳518118

出　　处：《海峡药学》2023年第3期58-61,共4页Strait Pharmaceutical Journal

摘　　要：1例84岁女性患者因“意识模糊7 h”平车入院,因诊断为脓毒性休克给予亚胺培南/西司他丁钠1 g,q12h,静脉滴注抗感染治疗。用药前患者白细胞计数为7.16×10^(9)/L、血小板计数为253.00×10^(9)/L,用药3d后,患者白细胞计数为1.78×10^(9)/L,血小板计数为37.00×10^(9)/L。停用亚胺培南/西司他丁钠,给予重组人粒细胞刺激因子注射液150μg,皮下注射,1个治疗量血小板治疗后,患者白细胞计数升高至12.81×10^(9)/L,血小板计数升高至175.00×10^(9)/L。本例提示老年患者应慎用亚胺培南/西司他丁钠,并在治疗期间加强监测。An 84-year-old female patient was admitted with“unconsciousness for 7 hours”by flat car and was given imipenem/cilastatin sodium 1 g,q12h,intravenous antiinfective therapy for septic shock.Before medication,the patient′s white blood cell count was 7.16×10^(9)/L and platelet count was 253.00×10^(9)/L;after 3 days of medication,the patient′s white blood cell count was 1.78×10^(9)/L and platelet count was 37.00×10^(9)/L.After imipenem/cilastatin sodium were stopped,recombinant human granulocyte stimulating factor injection 150μg was given subcutaneously,and one therapeutic dose of platelet was given.After treatment,the white blood cell count increased to 12.81×10^(9)/L and platelet count increased to 175.00×10^(9)/L.This case suggests that imipenem/cilastatin sodium should be used with caution in elderly patients and surveillance should be strengthened during treatment.

关 键 词：亚胺培南/西司他丁钠 白细胞减少 血小板减少 

分 类 号：R969.3[医药卫生—药理学]