滤泡辅助性T细胞在原发性干燥综合征中的研究进展  

Research progress on follicular helper T cells in primary Sjogren’s syndrome

作　　者：张笑宇 陆辰康 钮晓音[1] ZHANG Xiao-yu;LU Chen-kang;NIU Xiao-yin(Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Stomatology of Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 20001l,China)

机构地区：[1]上海交通大学医学院上海市免疫学研究所,上海200025 [2]上海交通大学医学院附属第九人民医院,上海交通大学口腔医学院,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《现代免疫学》2023年第2期150-154,161,共6页Current Immunology

基　　金：国家自然科学基金(81871269);上海市卫生和计划生育委员会科研课题面上项目(201640137,202140095);上海交通大学医学院2020年度RBL项目。

摘　　要：滤泡辅助性T细胞(follicular helper T cell,Tfh)是辅助B细胞的主要CD4+T细胞亚群,其特点是表达转录因子B细胞淋巴瘤6(B-cell lymphoma 6,Bcl-6)以及趋化因子受体5(C-X-C chemokine receptor type 5,CXCR5)、诱导性共刺激分子(inducible co-stimulator,ICOS)、PD-1等表面分子和产生细胞因子IL-21。Tfh的分化是一个多步骤、多因素参与的过程。原发性干燥综合征(primary Sjogren’s syndrome,pSS)是一种以外分泌腺局灶性淋巴细胞浸润为特点的全身性自身免疫性疾病。越来越多的研究表明,Tfh参与pSS的发病过程,是pSS的潜在生物标志物,一些治疗pSS的药物可影响Tfh从而缓解病情。该文对近年来Tfh在pSS中的研究进展进行综述。The follicular helper T cell(Tfh) is a subset of CD4^(+)T cells that facilitate B cell functions. Tfh is characterized bythe expression of transcriptional factor B-cell lymphoma 6(Bcl-6) and surface molecules including C-X-C chemokine receptor type 5(CXCR5), inducible co-stimulator(ICOS), PD-1 and cytokine IL-21. The differentiation of Tfh is a multi-step process that involves multiple factors. Primary Sjogren’s syndrome(pSS) is a systemic autoimmune disease characterized by focal lymphocyte infiltration of exocrine glands. Numerous studies have revealed that Tfh participates in pSS pathogenesis and is a potential biomarker of pSS. Some pSS treatments may alleviate the symptoms by affecting Tfh. This review focuses on the current research progress on Tfh in pSS.

关 键 词：滤泡辅助性T细胞 原发性干燥综合征 滤泡调节性T细胞 

分 类 号：R593.2[医药卫生—内科学]