激素联合长效β2激动剂吸入治疗慢性阻塞性肺疾病稳定期患者的效果观察  

Clinical effect of inhaled corticosteroid combined with long-actingβ2 agonist in the treatment of stable chronic obstructive pulmonary disease

作　　者：卢奎斌 贾宗岭 Lu Kuibin;Jia Zongling(Department of Respiratory Medicine,Second People’s Hospital of Henan Province,Affiliated Hospital of Henan Medical College,Xinzheng 451191,China;Department of Respiratory and Critical Care,Second People’s Hospital of Henan Province,Affiliated Hospital of Henan Medical College,Xinzheng 451191,China)

机构地区：[1]河南省第二人民医院、河南医学高等专科学校附属医院呼吸内科,新郑451191 [2]河南省第二人民医院、河南医学高等专科学校附属医院呼吸与危重症科,新郑451191

出　　处：《中国实用医刊》2023年第1期101-103,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)稳定期患者采用激素联合长效β2激动剂吸入治疗的效果。方法抽取2020年1月至2022年1月河南省第二人民医院收治的90例COPD稳定期患者,采用双色球法分为对照组与观察组,每组45例。两组均采取常规治疗,对照组加用长效β2激动剂吸入治疗,观察组加激素联合长效β2激动剂吸入治疗。比较两组治疗前后的肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流量(PEF)]、血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]及不良反应发生情况。结果治疗前,两组肺功能指标、血气分析指标比较差异未见统计学意义(P>0.05);治疗后,观察组FEV1、FVC、PEF及PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(4.44%,2/45)与对照组(8.89%,4/42)比较差异未见统计学意义(P>0.05)。结论 COPD稳定期治疗方案中应用激素联合长效β2激动剂治疗的效果较好,能更好地改善患者的血气分析指标及肺功能。Objective To investigate the therapeutic effect of inhaled corticosteroid combined with long-actingβ2 agonists on stable chronic obstructive pulmonary disease(COPD).Methods A total of 90 patients with stable COPD treated in the Second People’s Hospital of Henan Province from January 2020 to January 2022 were selected.And they were divided into control group and observation group by the two-sphere method,with 45 cases in each group.Both groups were treated by conventional treatment,in addition,the control group was treated with long-actingβ2 agonist inhalation,and the observation group was treated with corticosteroid combined with long-actingβ2 agonist.The pulmonary function indexes including forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF),blood gas analysis indexes including arterial partial pressure of oxygen(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2)),and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in pulmonary function indexes or blood gas analysis indexes between the two groups(P>0.05).After treatment,compared with the control group,the observation group had higher FEV1,FVC,PEF and PaO_(2),but lower PaO_(2)(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(4.44%,2/45)and the control group(8.89%,4/42),P>0.05.Conclusions The inhaled corticosteroid combined with long-actingβ2 agonist in the treatment of stable COPD has a good curative effect,and it can better improve blood gas analysis indexes and pulmonary function.

关 键 词：慢性阻塞性肺疾病 激素 长效β激动剂 联合治疗 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]