人类免疫缺陷病毒/乙型肝炎病毒合并感染者CD4^(+)T细胞计数和乙型肝炎病毒复制、中性粒细胞与淋巴细胞比值水平的相关性  

Correlation of CD4^(+) T cell count and hepatitis B virus replication, neutrophil- to-lymphocyte ratio in human immunodeficiency virus/hepatitis B virus co-infected patients

作　　者：杨杨 刘付弟 曾方林 YANG Yang;LIU Fudi;ZENG Fanglin(Department of Laboratory Medicine,Affiliated Hospital of Yangzhou University,Jiangsu Province,Yangzhou225000,China)

机构地区：[1]扬州大学附属医院检验科,江苏扬州225000

出　　处：《中国医药导报》2023年第10期145-148,共4页China Medical Herald

基　　金：江苏省自然科学基金资助项目(SBK2018040809)。

摘　　要：目的探讨人类免疫缺陷病毒(HIV)/乙型肝炎病毒(HBV)合并感染者CD4^(+)T细胞计数和HBV复制、中性粒细胞与淋巴细胞比值(NLR)的相关性。方法回顾性分析2018年2月至2022年1月扬州大学附属医院收治的59例HBV单纯感染者(HBV组)与76例HIV/HBV合并感染者(HIV/HBV组)的临床资料。HIV/HBV组根据CD4^(+)T细胞计数分为A组(CD4^(+)T细胞计数>200个/μl,31例)和B组(CD4^(+)T细胞计数≤200个/μl,45例)。比较HBV组与HIV/HBV组CD4^(+)T细胞计数、HBV DNA水平及NLR,进一步比较A组与B组的HBV DNA水平及NLR,分析HIV/HBV合并感染者CD4^(+)T细胞计数与HBV DNA水平及NLR的相关性。结果HIV/HBV组CD4^(+)T细胞计数、HBV DNA水平低于HBV组,NLR高于HBV组,差异有统计学意义(P<0.05)。A组HBV DNA水平及NLR均低于B组,差异有统计学意义(P<0.05)。HIV/HBV组CD4^(+)T细胞计数与HBV DNA水平及NLR均呈负相关(r<0,P<0.05)。结论HIV/HBV合并感染者CD4^(+)T细胞计数降低,HBV DNA复制更加活跃,对临床指导用药具有重要意义。Objective To investigate the correlation of CD4^(+)T cell count and hepatitis B virus(HBV)replication,neutrophil-to-lymphocyte ratio(NLR)in human immunodeficiency virus(HIV)/HBV co-infected patients.Methods The clinical data of 59 patients with HBV simplex infection(HBV group)and 76 patients with HIV/HBV co-infection(HIV/HBV group)admitted to the Affiliated Hospital of Yangzhou University from February 2018 to January 2022 were retrospectively analyzed.According to CD4^(+)T cell count,the HIV/HBV group was divided into group A(CD4^(+)T cell count>200/μl,31 cases)and group B(CD4^(+)T cell count≤200/μl,45 cases).The CD4^(+)T cell count,HBV DNA level,and NLR were compared between HBV group and HIV/HBV group,and the HBV DNA level and NLR were further compared between group A and group B,and the correlation between the CD4^(+)T cell count and HBV DNA level,NLR was analyzed in HIV/HBV co-infected patients.Results CD4^(+)T cell count and HBV DNA level in HIV/HBV group were lower than those in HBV group,while NLR was higher than that in HBV group,the differences were statistically significant(P<0.05).The HBV DNA level and NLR in group A were lower than those in group B,the differences were statistically significant(P<0.05).CD4^(+)T cell count was negatively correlated with HBV DNA level and NLR in HIV/HBV group(r<0,P<0.05).Conclusion In HIV/HBV co-infected patients,CD4^(+)T cell count is decreased and HBV DNA replication is more active,which has important significance for clinical drug guidance.

关 键 词：人类免疫缺陷病毒 乙型肝炎病毒 CD4^(+)T细胞 病毒复制 中性粒细胞与淋巴细胞比值 相关性 

分 类 号：R511[医药卫生—内科学]