猪δ冠状病毒对先天免疫信号转导通路的影响  

Effects of Porcine Deltacoronavirus on the Transduction Pathway of the Innate Immune Signal

作　　者：孟凡茹[1] 闫炎 魏语泽 张昊 赵伟[1] 裴志花[1] 王开[1] 胡桂学[1] MENG Fanru;YAN Yan;WEI Yuze;ZHANG Hao;ZHAO Wei;PEI Zhihua;WANG Kai;HU Guixue(College of Veterinary Medicine,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]吉林农业大学动物医学院,长春130118

出　　处：《经济动物学报》2023年第1期74-78,共5页Journal of Economic Animal

基　　金：吉林省重点研发项目(20200402055NC);国家自然科学基金项目(32072857)。

摘　　要：猪δ冠状病毒(Porcine deltacoronavirus,PDCoV)是一种新型猪肠道冠状病毒,可靶向感染猪小肠绒毛上皮细胞,引起严重肠炎。PDCoV感染宿主后,通过拮抗或逃避先天免疫信号转导通路完成在宿主体内的增殖。为了解PDCoV对先天免疫信号转导通路的作用机制,通过综述PDCoV对RLR信号通路、JAK-STAT信号通路、MAPK信号通路、线粒体信号通路的作用,阐明PDCoV与宿主先天免疫信号转导通路之间的关系,以期为PDCoV的防治提供帮助。Porcine deltacoronavirus(PDCoV)is a new type of pig intestinal coronavirus,which targets pig small intestinal epithelial cells to cause severe enteritis.After infecting the host,PDCoV finishes its proliferation in the host cell by antagonism or escape the innate immune signaling transduction pathway.In order to understand the action mechanism of PDCoV on the congenital immune signal transduction pathways,this paper reviews the effects of PDCoV on RLR,Jak-STAT,MAPK and mitochondrial signaling pathway to clarify the relationship between PDCoV and host innate immune signaling transduction pathways in order to provide help for the prevention and treatment of PDCoV infection.

关 键 词：猪δ冠状病毒 先天免疫 信号通路 

分 类 号：S823[农业科学—畜牧学]