消化道微生态与胆石症关系研究进展  

Relationship between gastrointestinal microecology and gallstone disease:research progress

作　　者：吴振坤 张先卓 曹洁[3] 岳平[2] 孟文勃[2] 林延延[2] WU Zhen-kun;ZHANG Xian-zhuo;CAO Jie;YUE Ping;MENG Wen-bo;LIN Yan-yan(The First School of Clinical Medicine,Lanzhou University,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院普外科 [3]兰州大学第一医院检验科

出　　处：《中国微生态学杂志》2023年第3期366-369,共4页Chinese Journal of Microecology

基　　金：国家自然科学基金地区科学基金(32160255);兰州大学第一医院院内基金项目(ldyyyn2019-58)。

摘　　要：胆石症(gallstone disease,GSD)是消化外科领域常见的疾病,严重影响机体健康。既往研究发现GSD形成机制可能与饮食习惯、肥胖、遗传因素及基因调控水平、胆汁胆固醇过饱和、胆囊运动障碍和胆汁排出受阻、黏蛋白异常积累和胆汁酸代谢障碍等有关。近年来随着宏基因组鸟枪测序及16S rRNA基因测序等分子生物学技术的广泛应用,大量研究发现消化道微生态(包括口腔微生态、胆道微生态和肠道微生态等)与胆道结石的形成密切相关。本文对消化道微生态与GSD关系的相关研究进行梳理与综述,旨在为GSD的预防、治疗和改善预后提供新的策略。Gallstone disease(GSD)is a common disease,which seriously affects people's health.Previous studies have found that the formation mechanism of GSD may be related to diet,obesity,genetic factors and gene regulation levels,bile cholesterol oversaturation,gallbladder dyskinesia and obstruction of bile excretion,mucin accumulation and bile acid metabolism disorders and so on.In recent years,with the widespread application of molecular biology technology such as wholemetagenome shotgun sequencing(WMS)and 16S rRNA gene sequencing,a large number of studies have suggested that the microbiome of digestive tract including oral microbiota,biliary microbiota and gut microbiota,are closely related to the formation of gallstones.This study reviewed the correlation between gastrointestinal microecology and GSD to provide new strategies for the prevention,treatment and prognosis improvement of the disease.

关 键 词：胆石症 微生态 胆道 肠道菌群 口腔菌群 

分 类 号：R657.4[医药卫生—外科学]