2型糖尿病患者低血糖感知受损的研究进展  

Research progress of impaired perception of hypoglycemia in patients with type 2 diabetes

作　　者：王雅静 方彭华 张真稳 Wang Yajing;Fang Penghua;Zhang Zhenwen(Department of Endocrinology,Clinical Medical College,Yangzhou University,Yangzhou 225001,China;The Experimental Research Center of Clinical Medicine,the First School of Clinical Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]扬州大学临床医学院内分泌科,扬州225001 [2]南京中医药大学第一临床医学院临床医学实验研究中心,南京210023

出　　处：《国际内分泌代谢杂志》2023年第2期132-135,共4页International Journal of Endocrinology and Metabolism

基　　金：江苏省中医药科技发展计划项目(YB2020087);国家自然科学基金(81803792)。

摘　　要：低血糖感知受损指患者对低血糖的感知能力减弱或缺失的一种现象。目前,低血糖感知受损的评估主要为葡萄糖钳夹实验及问卷法,近年研究发现负反馈调节异常、中枢及周围神经系统调节异常均可能参与了低血糖感知受损的发生。连续血糖监测等手段也为低血糖感知受损的缓解提供新的方向。现对2型糖尿病患者的低血糖感知受损的评估、发生机制等研究进展进行综述。Impaired awareness of hypoglycaemia is a phenomenon among patients with diabetes mellitus who weaken or lost their ability to perceive hypoglycemia symptoms.At present,the assessment of impaired awareness of hypoglycaemia mainly based on hyperinsulinemic-euglycemic clamp study and questionnaire.Recent studies have found that abnormal negative feedback regulation,abnormal central and peripheral nervous system regulation are probably involved in impaired awareness of hypoglycaemia,and continuous glucose monitoring also provide new directions for its treatment.This paper reviews the new progress of the assessment and pathogenetic mechanism of impaired awareness of hypoglycemia in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 低血糖感知受损 严重低血糖 

分 类 号：R587.1[医药卫生—内分泌]