FecB 基因在绵羊繁殖性能上的研究进展  

Research Progress of FecB Gene on Reproductive Performance of Sheep

作　　者：杨初蕾 张译元[2] 唐红[2] 郭延华[2] 任秀美奥 王立民 周平[1,2] YANG Chulei;ZHANG Yiyuan;TANG Hong;GUO Yanhua;REN Xiumeiao;WANG Limin;ZHOU Ping(College of Animal Science and Technology,Shihezi University,Shihezi 832000,China;State Key Laboratory of Sheep Genetic Improvement and Healthy Production,Xinjiang Academy of Agricultural Reclamation Sciences,Shihezi 832000,China)

机构地区：[1]石河子大学动物科技学院,石河子832000 [2]新疆农垦科学院,省部共建绵羊遗传改良与健康养殖国家重点实验室,石河子832000

出　　处：《畜牧兽医学报》2023年第4期1370-1380,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：兵团科技创新人才计划(2021CB032);国家转基因重大专项(2016ZX08008001)。

摘　　要：绵羊的繁殖性能是一种十分重要的经济性状,绵羊产羔数与每次的排卵数直接相关,绵羊卵子的生长发育受到卵巢内分泌及旁分泌的相互作用。FecB基因是羊上首个被发现的多胎主效基因,携带该基因的绵羊卵巢中BMP信号通路受到损害而活性降低,TGF-β家族部分成员失活,抑制GCs增殖并提高FSH的敏感性,有效提高绵羊的排卵率和产羔率,有利于扩大养殖规模,提高经济效益。本文对FecB基因的发现、作用机制及其对卵泡发育、繁殖能力和后代生长发育的影响,以及育种方面的应用进行综述,以期为绵羊繁殖性能提升的机理研究和育种工作等提供参考和借鉴。The reproductive performance of sheep is a very important economic trait.The number of lambs is directly related to the number of ovulation each time,and the growth and development of ovum is influenced by the interaction of ovarian endocrine and paracrine.FecB gene is the first multifetal major gene discovered in sheep.The BMP signaling pathway in the ovary of sheep carrying this gene is damaged and the activity is reduced,and some members of TGF-βfamily are inactivated,which inhibits the proliferation of GCs and improves the sensitivity of FSH,effectively improves ovulation rate and lambing rate of sheep,which is conducive to expanding the breeding scale and improving economic benefits.In this paper,the discovery of FecB gene,its action mechanism,its effect on follicular development,reproductive ability and offspring growth and development,as well as its application in breeding were reviewed,in order to provide reference for the mechanism research and breeding work of improving sheep reproductive performance.

关 键 词：绵羊 FECB 繁殖性能 

分 类 号：S826.3[农业科学—畜牧学]