阻断CLTA-4/PD-1联合化疗药物在肿瘤治疗中的应用  

Application of blocking CLTA-4/PD-1 combined chemotherapy drugs in tumor treatment

作　　者：邰日升 李娜[1] 杨善茹 王庚[1] 雷蕾[1] 单智焱(指导)[1] TAI Risheng;LI Na;YANG Shanru;WANG Geng;LEI Lei;SHAN Zhiyan(Department of Histology and Embryology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学组织学与胚胎学教研室,哈尔滨150081

出　　处：《中国免疫学杂志》2023年第4期855-859,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(31741040);黑龙江省普通本科高等学校青年创新人才培养计划项目(UNPYSCT-2017053,UNPYSCT-2017054);黑龙江省博士后基金项目(LBH-Q17116,LBHZ17171)。

摘　　要：化学药物治疗(化疗)是目前治疗肿瘤最有效的手段之一,但单独应用化学药物存在肿瘤靶向能力差、副作用严重、容易导致肿瘤耐药等弊端。免疫治疗是通过重新启动并维持肿瘤-免疫循环,恢复机体正常抗肿瘤免疫反应,从而控制与清除肿瘤的治疗方法。免疫检查点抑制剂(ICIs)是免疫治疗中的一类常规药物,以抗程序性死亡蛋白1(PD-1)抗体和细胞毒性T淋巴细胞抗原4(CTLA-4)抑制剂为代表。研究者发现通过阻断CLTA-4或PD-1与化疗药物联用,不仅能发挥化疗药物对肿瘤的细胞毒作用,还可通过促进淋巴细胞的增殖与活化、弥补化学治疗抑制机体免疫的弊端、促进并维持记忆T细胞增殖等一系列促进免疫系统发挥作用的方式提高抗肿瘤效果。本文对联合治疗的实验室和临床研究模式,及其作用机制进行综述。Chemotherapy is currently one of the most effective means of treating tumors.However,application of chemical drugs alone has poor tumor targeting ability,has serious side effects,and can easily lead to disadvantages of tumor resistance.Immuno‐therapy is a treatment method that controls and clears the tumor by restarting and maintaining tumor-immune cycle to restore body's normal anti-tumor immune response.Immune checkpoint inhibitors(ICIs)are a class of conventional drugs in immunotherapy.They use anti-programmed death 1(PD-1)antibodies and cytotoxic T lymphocyte antigen 4(CTLA-4)inhibitors as representative.Researchers found that blocking CLTA-4 or PD-1 in combination with chemotherapeutic drugs can not only exert cytotoxic effect of chemotherapeutic drugs on tumors,but also inhibit body's immunity by promoting proliferation and activation of lymphocytes,making up for chemotherapy disadvantages,promoting and maintaining the proliferation of memory T cells and a series of ways to promote the functioning of immune system to improve the anti-tumor effect.This article reviews the laboratory and clinical research modes of combined therapy and its mechanism of action.

关 键 词：化学治疗 肿瘤免疫治疗 免疫检查点 CTLA-4 PD-1 

分 类 号：R392[医药卫生—免疫学]