蜕膜巨噬细胞与不明原因自然流产关系的研究进展  

Research progress on relationship between decidual macrophages and spontaneous abortion of unknown causes

作　　者：李娜[1] 马铭艳 杨美霞[1] 宋芳(指导)[1] LI Na;MA Mingyan;YANG Meixia;SONG Fang(Department of Histology and Embryology,Baotou Medical College,Baotou 014040,China)

机构地区：[1]包头医学院组织学与胚胎学教研室,包头014040

出　　处：《中国免疫学杂志》2023年第4期885-889,共5页Chinese Journal of Immunology

基　　金：2021年内蒙古自治区自然科学基金项目(2021MS08056);2022年度内蒙古自治区卫生健康科技计划项目(202201393)。

摘　　要：母胎界面多种蜕膜免疫细胞在免疫耐受中发挥作用,其中蜕膜巨噬细胞(DM)是母胎界面数量较多的免疫细胞,可分为M1型和M2型。DM向M2型极化时,机体维持正常妊娠;DM向M1型极化时,会引发自然流产(SA)。DM参与绒毛外滋养细胞侵袭、螺旋动脉重塑和免疫耐受等过程,一旦这些功能异常就会引发SA。本文对DM表型、功能及其与SA的关系进行综述。Many decidual immune cells in maternal-fetal interface play a role in immune tolerance,and decidual macrophages(DM)have a large number among them,which are divided into two types:M1 and M2.Normal pregnancy is maintained when DM polarized to M2 type,and spontaneous abortion(SA)will be induced when DM polarized to M1 type.DM is involves in processes of extravillous trophoblast invasion,spiral artery remodeling,immune tolerance,and SA will occur once these functions are abnormal.Therefore,phenotype and function of DM and their relationship with SA are reviewed in this paper.

关 键 词：蜕膜巨噬细胞 自然流产 母胎界面 M1/M2极化 

分 类 号：R714.[医药卫生—妇产科学]