粪菌移植改善猪肠道屏障功能的研究进展  

Research Progress of Fecal Microbiota Transplantation in Improving Intestinal Barrier Function in Pigs

作　　者：田玉 杨玲媛[1] 黄兴国[1] 尹杰[1] TIAN Yu;YANG Lingyuan;HUANG Xingguo;YIN Jie(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128

出　　处：《动物营养学报》2023年第4期2072-2080,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金联合基金项目(U20A2055)。

摘　　要：肠道菌群是动物肠道系统组成的重要部分,对动物肠道发育和免疫功能成熟起着重要的作用,而且肠道菌群失衡与多种肠道疾病有关。粪菌移植(FMT)是一种将健康供体粪便菌群移植到患病受体肠道内,通过改善肠道菌群治疗肠道疾病的方法,是改善肠道菌群最直接、快速、有效的方法之一。近期的研究表明,FMT对畜禽肠道健康和生长性能有积极作用,可调节肠道菌群、维护肠道机械屏障、改善肠道黏液环境、提高肠道免疫力,对于维护肠道健康有很好的效果。本文综述了FMT对猪肠道屏障的影响,探讨了FMT的安全性和注意事项,以期为FMT技术在猪生产上更加安全规范的应用提供参考。Intestinal flora is an important part of animal intestinal system and plays an important role in intestinal development and immune function maturation.Moreover,imbalance of intestinal flora is related to a variety of intestinal diseases.Fecal microbiota transplantation(FMT)is one of the most direct,rapid and effective methods to improve the intestinal flora by transplanting healthy donor fecal bacteria into the recipient and treating intestinal diseases by improving the intestinal flora.Recent studies have shown that FMT has a positive effect on the intestinal health and growth performance of livestock and poultry.It can regulate the intestinal flora,maintain the intestinal mechanical barrier,improve the intestinal mucus environment,promote intestinal immunity,and has a good effect on maintaining intestinal health.This paper reviewed the effects of FMT on intestinal barrier of pigs,and discussed the safety and precautions of FMT,in order to provide reference for the application of FMT technology in pig production.

关 键 词：粪菌移植 肠道屏障 肠道免疫 猪 

分 类 号：S828[农业科学—畜牧学]