前列地尔对下肢动脉硬化闭塞症经皮腔内血管介入治疗后血管内再狭窄的影响  

Effect of postoperative intravascular restenosis at percutaneous transluminal angioplast or stent implantation in lower extremity arteriosclerosis obliterans

作　　者：李普升 刘擎 何珊 刘培中 李创鹏 段勇 Li Pusheng;Liu Qing;He Shan;Liu Peizhong;Li Chuangpeng;Duan Yong(Department of Intervention,Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine(the Second Affiliated Hospital of Guangzhou University of Chinese Medicine),Zhuhai 519000,Guangdong,China;Department of Cardiovascular Medicine,the Third Hospital of Changsha,Changsha 410000,Hu'nan,China)

机构地区：[1]广东省中医院珠海医院(广州中医药大学第二附属医院)介入科,广东珠海519000 [2]长沙市第三医院心血管内科,湖南长沙410000

出　　处：《血管与腔内血管外科杂志》2023年第3期319-322,共4页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨前列地尔对下肢硬化闭塞症(ASO)患者经皮腔内血管成形术(PTA)或支架植入术后发生血管内再狭窄的影响。方法收集2019年1月至2021年12月于广东省中医院珠海医院(广州中医药大学第二附属医院)就诊的29例ASO患者的临床资料。根据围手术期是否使用前列地尔将其分为治疗组(n=14,26条血管)和对照组(n=15,25条血管)。比较两组患者术后6个月血管内再狭窄发生情况,分析ASO患者PTA或支架植入术后发生血管内再狭窄的影响因素。结果术后6个月内,血管内再狭窄率为47.1%(24/51),两组患者血管内再狭窄程度比较,差异无统计学意义(P﹥0.05)。单因素及多因素分析结果显示,前列地尔、高血压、糖尿病、C反应蛋白水平均不是发生血管内再狭窄的影响因素(P﹤0.05)。结论围手术期使用前列地尔对下肢PTA或支架植入术后发生血管内再狭窄的影响未见明显差异,可能与样本量相对较小有关。Objective To investigate the effect of postoperative intravascular restenosis at percutaneous transluminal angioplast(PTA)or stent implantation in patients with lower extremity arteriosclerosis obliterans.Method The clinical data of 29 ASO patients who were treated in Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine(the Second Affiliated Hospital of Guangzhou University of Chinese Medicine)from January 2019 to December 2021 were collected.They were divided into treatment group(n=14,26 blood vessels)and control group(n=15,25 blood vessels)according to whether to use alprostadil in the perioperative period.The occurrence of intravascular restenosis six months after the operation was compared between the two groups,and the influencing factors of intravascular restenosis after PTA or stent implantation in ASO patients were also analyzed.Result Within six months after the operation,the intravascular restenosis rate was 47.1%(24/51),there was no significant difference in the degree of intravascular restenosis between the two groups(P>0.05).The results of univariate and multivariate analysis showed that alprostadil,hypertension,diabetes,and C-reactive protein levels were not the influencing factors of intravascular restenosis(P<0.05).Conclusion There is no significant difference in the effect of perioperative intravenous alprostadil on the degree of intravascular restenosis after PTA or stent implantation,which could not be ruled out because of the relatively small sample size.

关 键 词：前列地尔 再狭窄 下肢动脉硬化闭塞症 血管成形术 

分 类 号：R543.6[医药卫生—心血管疾病]