2022年中国肾移植研究年度盘点  

Research highlights on kidney transplantation in 2022 from China

作　　者：魏健超 何凯鸣 孙启全 Wei Jianchao;He Kaiming;Sun Qiquan(Department of Kidney Transplantation,Guangdong Provincial People's Hospital Affiliated to Southern Medical University,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)肾移植科,广州510080

出　　处：《器官移植》2023年第3期336-342,共7页Organ Transplantation

基　　金：国家自然科学基金面上项目(81970650、82270783)。

摘　　要：肾移植作为成熟的器官移植手术已成为治疗终末期肾病的最优手段,提高了患者的生存质量。但目前肾移植术后依然面临排斥反应、感染、缺血-再灌注损伤、移植肾纤维化等诸多挑战,严重影响肾移植的疗效。伴随转化医学、再生医学、生物材料等新兴领域的发展,我国研究团队不断努力,为解决各种肾移植临床相关问题发表了许多亮眼研究。本文就2022年度肾移植基础与临床相关的前沿以及移植领域的新技术、新进展进行综述,关注中国团队2022年在移植领域取得的成果,以本土化的视角为解决为肾移植的重大临床问题提供思路,促进我国肾移植的进一步发展。As a mature organ transplantation surgery,kidney transplantation has become the best means for treating end-stage renal diseases and improves the quality of survival of patients.However,there are still many challenges after kidney transplantation,such as rejection,infection,ischemia-reperfusion injury and fibrosis of transplant kidney,which seriously affect the efficacy of kidney transplantation.With the development of translational medicine,regenerative medicine,biomaterials and other emerging fields,Chinese research teams continue to work hard and publish many bright researches to solve various clinical problems related to kidney transplantation.This article reviews the basic and clinical frontiers of kidney transplantation in 2022 as well as the new techniques and advances in the field of transplantation,focuses on the achievements made by the Chinese team in the field of transplantation in 2022,and provides ideas for solving the major clinical problems of kidney transplantation from the perspective of localization to promote the further development of kidney transplantation in China.

关 键 词：肾移植 排斥反应 缺血-再灌注损伤 感染 炎症反应 慢性移植物功能障碍 移植物功能延迟恢复 纤维化 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]