宿主靶向抗乙型肝炎病毒治疗策略研究新进展  

Perspective on host-targeted therapeutic antiviral strategies for patients with chronic hepatitis B

作　　者：方慧晶(综述) 朱传龙 章莉莉(审校) Fang Huijing;Zhu Chuanlong;Zhang Lili(Department of Infectious Diseases,First Affiliated Hospital,Nanjing Medical University,Nanjing 210000,Jiangsu Province,China)

机构地区：[1]南京医科大学第一附属医院感染病科,南京市210000 [2]海南医学院第二附属医院感染病与热带病科

出　　处：《实用肝脏病杂志》2023年第3期449-452,共4页Journal of Practical Hepatology

基　　金：海南省科技厅重点研发项目(编号:ZDYF2022SHFZ067)。

摘　　要：乙型肝炎病毒(HBV)感染是肝脏疾病进展甚至癌变的重要病因。HBV的完整生命周期依赖于宿主细胞,因此囊括了抑制病毒进入、破坏病毒核酸稳定性和增强宿主对HBV免疫反应等的靶向宿主细胞抗病毒(host-targeting antiviral, HTA)治疗方案颇有前景。本文综述了通过靶向作用于宿主和宿主因子,从而达到抗病毒作用的药物研发进展,以期为后续抗病毒研究和临床治疗提供选择手段。Chronic hepatitis B virus infection is an important factor in the progression of liver disease and hepatocellular carcinoma.The complete life cycle of hepatitis B virus is dependent on the host cell,which makes host-targeting antiviral(HTA)treatment options promising.The HTA includes inhibition of virus entry,destabilization of viral nucleic acids and enhancement of host immune response to HBV infection.This paper reviewed the development of medicines that target hosts and host factors in order to achieve the goal of hepatitis B virus suppression,with a view to providing a reference for subsequent antiviral research and clinical treatment.

关 键 词：慢性乙型肝炎 宿主靶向 抗病毒治疗 

分 类 号：R512.62[医药卫生—内科学]