芳香胺类化合物的二氟烷基化研究进展  

Research Progress on Difluoroalkylation of Aromatic Amine

作　　者：朱兴梨 王花 何炜 ZHU Xingli;WANG Hua;HE Wei(Chemistry and Environment Science institute,Shaanxi University of Technology,Hanzhong 723001,China;Department of Pharmacy,Air Force Military Medical University,Xi′an 710032,China)

机构地区：[1]陕西理工大学化学与环境科学学院,陕西汉中723001 [2]空军军医大学药学系,陕西西安710032

出　　处：《合成化学》2023年第4期262-275,共14页Chinese Journal of Synthetic Chemistry

基　　金：陕西省重点研发产业创新链课题(2019ZDLSF03-03)。

摘　　要：含氟化合物具有独特的物理化学特性,被广泛应用于药物开发、临床医学、农业化学、材料科学和有机合成等领域。过去几十年里,利用含氟砌块策略将含氟官能团引入有机分子中引起了合成化学家们的广泛关注,特别是利用二氟烷基化试剂合成具有重要价值的含氟分子方面取得了重要进展。本文聚焦于总结芳香胺类化合物的二氟烷基化反应,按照金属催化、可见光催化以及其它方法对近年来文献报道的芳香氮杂化合物的二氟烷基化反应进行介绍,并对反应机理进行探究,期望为该类含氟化合物的合成及进一步应用提供方法和思路。Fluorine-containing compounds have unique physical and chemical characteristics and are widely used in drug development,clinical medicine,agricultural chemistry,material science and organic synthesis.In the past few decades,the introduction of fluorine-containing functional groups into organic molecules by using fluorine-containing block strategy has attracted wide attention of synthetic chemists,especially the rapid progress in synthesizing fluorine-containing molecules with difluoroalkylation reagents.This review focuses on summarizing the difluoroalkylation reaction of aromatic nitrogen compounds reported in recent years according to the methods of metal catalysis,visible photocatalysis and others.The reaction mechanism are also discussed,hoping to provide methods and ideas for the synthesis of this kind of fluorine-containing compounds and further applications.

关 键 词：二氟烷基化 过渡金属催化 光催化 C-H功能化 

分 类 号：O621.3[理学—有机化学]