可见光催化下N-芳基甲基丙烯酰胺的二氟甲基化/环化反应研究  

Study on Difluoromethylation/Cyclization of N-Arylmethacrylamides under Visible Light Catalysis

作　　者：罗蛟 黄丹凤[1] 王克虎[1] 胡雨来[1] LUO Jiao;HUANG Danfeng;WANG Kehu;HU Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730000,China)

机构地区：[1]西北师范大学化学与化工学院,甘肃兰州730000

出　　处：《合成化学》2023年第4期276-282,共7页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(22061037)。

摘　　要：研究了利用二氟乙酸酐作为二氟甲基自由基源,在可见光催化下的N-芳基甲基丙烯酰胺的二氟甲基化/环化反应,合成了一系列3-甲基-3-二氟乙基吲哚酮类化合物。结果表明:该方法操作简单,产率较高,可达91%,底物适用范围广。The study of a visible-light catalyzed radical difluoromethylation/cyclization of N-arylmethacrylamides with difluoroacetic anhydride as difluoromethyl source.A series of 3-methyl-3-difluoroethylindolone compounds were synthesized.The results showed that the method has the advantages of simple operation,high yield up to 91%and wide application range of substrate.

关 键 词：二氟甲基 光催化 N-芳基甲基丙烯酰胺 二氟乙酸酐 甲基化/环化反应 

分 类 号：O622.4[理学—有机化学]