利用单光纤光镊实现不同折射率的微粒分选  

Particle sorting with different refractive indices using single fiber optical tweezers

作　　者：钟慧 高丙坤[1] 党雨婷 赵忖[2] 姜春雷[1] ZHONG Hui;GAO Bingkun;DANG Yuting;ZHAO Cun;JIANG Chunlei(College of Electrical Information Engineering,Northeastern Petroleum University,Daqing 163318,China;Department of Electrical Information Engineering,Northeast Petroleum University,Qinhuangdao Campus,Qinhuangdao 066004,China)

机构地区：[1]东北石油大学电气信息工程学院,黑龙江大庆163318 [2]东北石油大学秦皇岛校区电气信息工程系,河北秦皇岛066004

出　　处：《光学精密工程》2023年第8期1115-1123,共9页Optics and Precision Engineering

基　　金：黑龙江自然科学基金资助项目(No.LH2021F008)。

摘　　要：为解决在进行不同折射率的微粒分类时遇到的问题,本文提出了一种采用熔融法拉伸的抛物线型光纤探针,所得到的出射光场对于浸没在水溶液中的不同折射率的微粒具有不同的操作能力,可以达到微粒分类的目的。我们将波长为980 nm的激光通入光纤探针中,操控光纤在液体中实现对二氧化硅(SiO_(2))、聚苯乙烯(PS)和酵母菌细胞三种不同折射率的微粒及细胞的捕获和传输,进而实现不同微粒的分类。基本上实现了对三种微粒在1~10μm范围内的操控和分类。通过仿真验证了这种抛物线型光纤探针对三种微粒具有不同捕获能力,所得到的理论和实验结果保持一致。使用该方法对微粒进行分类,可以简化实验装置,并且在无标签混合光纤传感器的开发和传染病检测或细胞分类等方面有广泛应用。In order to solve the problems encountered in classifying particles with different refractive indi⁃ces,this paper proposes a parabolic fiber optic probe stretched by the fusion method;the resulting outgo⁃ing light field has different operating capabilities for particles with different refractive indices submerged in aqueous solutions,which can be used for particle classification.We couple a laser beam with a wavelength of 980 nm into the fiber optic probe and manipulate the fiber to achieve the capture and transport of parti⁃cles and cells with three different refractive indices in liquid:silicon dioxide(SiO_(2)),polystyrene(PS),and yeast cells,and thus achieve the classification of different particles in the range of 1-10μm.The differ⁃ent capture capabilities of this parabolic fiber optic probe for the three particles were simulated,and the ob⁃tained theoretical and experimental results were in agreement.The use of this method to classify particles simplifies the experimental setup and has a wide range of potential applications in the development of labelfree hybrid fiber optic sensors,infectious disease detection,and cell classification.

关 键 词：光纤光镊 折射率 细胞筛选 微粒分类 

分 类 号：Q631[生物学—生物物理学]