补体C1q肿瘤坏死因子相关蛋白9与其受体的相互作用  

The Interaction Between C1q and Tumor Necrosis Factor-Related Protein 9 and Its Receptors

作　　者：路旭阳 焦凯 刘德敏[1] 剧红娟[2] 谷国强[1] LU Xuyang;JIAO Kai;LIU Demin;JU Hongjuan;GU Guoqiang(Department of Cardiology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;Department of Ultrasound Medicine,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北医科大学第二医院心内科,河北石家庄050000 [2]河北医科大学第二医院超声科,河北石家庄050000

出　　处：《心血管病学进展》2023年第4期336-340,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82100301);河北省自然科学基金精准医学联合基金培育项目(H2021206220);2022年度河北省医学科学研究课题计划(20220989)。

摘　　要：补体C1q肿瘤坏死因子相关蛋白9(CTRP9)是一种分泌型糖蛋白,对心血管系统具有保护作用,是近年发现的CTRPs蛋白质家族中研究最多的成员之一。CTRP9通过与其受体相互作用,影响机体心血管系统及其他多种系统。CTRP9的受体目前已知主要有脂联素受体1、脂联素受体2和N-钙黏蛋白,上述受体可介导CTRP9调节能量代谢平衡、减轻炎症等作用。了解CTRP9受体的分布及CTRP9与受体间的相互作用关系将对保证CTRP9发挥有益的生理作用具有重要意义。现就CTRP9在生理病理过程中通过受体发挥的调节功能的研究做一综述,为更进一步了解CTRP9与受体间的相互作用关系提供理论依据。C1q and tumor necrosis factor-related protein 9(CTRP9)is a secreted glycoprotein,which has protective effect on cardiovascular system.It is one of the most studied members of CTRP protein family discovered in recent years.CTRP9 affects the cardiovascular system and many other systems by interacting with its receptors.At present,the receptors of CTRP9 are mainly known as adiponectin receptor 1,adiponectin receptor 2 and N-cadherin.These receptors can mediate the function of CTRP9 in regulating energy metabolism balance and reducing inflammation.Learning the distribution of CTRP9 receptors and the interaction between CTRP9 and its receptors will be of great significance to ensure that CTRP9 exerts a beneficial physiological function.Therefore,this article mainly reviews the researches about the regulatory function of CTRP9 through receptors in physiological and pathological processes,and provides theoretical basis for further understanding the interaction between CTRP9 and its receptors.

关 键 词：补体C1q肿瘤坏死因子相关蛋白9 脂联素受体1 脂联素受体2 N-钙黏蛋白 

分 类 号：R341[医药卫生—基础医学]