黏度法测定化妆品用原料透明质酸钠平均相对分子质量的不确定度评定  

Uncertainty Evaluation and Determination of Average Relative Molecular Weight for Cosmetic Raw Material Sodium Hyaluronate by Viscosity Method

作　　者：王秀娟 穆淑娥 闫婷婷 李敏 崔玉磊 WANG Xiujuan;MU Shue;YAN Tingting;LI Min;CUI Yulei(Bloomage Biotechnology Co.,Ltd.)

机构地区：[1]华熙生物科技股份有限公司品质管理中心

出　　处：《中国标准化》2023年第7期191-195,共5页China Standardization

摘　　要：本文依据CNAS-GL006:2019《化学分析中不确定度的评估指南》和JJF1059.1-2012《测量不确定度评定与表示》不确定评定程序,建立化妆品用原料透明质酸钠平均相对分子质量测定不确定度的数学模型,研究分析了整个测定过程中各种不确定度因素并进行评定,确定不确定度分量及合成不确定度。结果表明:当测定结果为1.41×10^(6)Da时,其扩展不确定度为0.04×10^(6)Da(k=2),方法重复性引入的不确定度贡献较大。通过对测量不确定度的评定,可以更客观科学地评价该测量结果。According to the procedure for uncertainty assessment descried in Guidance on Quantifying Uncertainty in Chemical Analysis(CNAS-GL006:2019)and Evaluation and Expression of Uncertainty in Measurement(JJF 1059.1-2012),the mathematical model of the uncertainty in the determination of average relative molecular weight of sodium hyaluronate was established.Various uncertainty factors in the whole determination process were studied and analyzed,and the uncertainty component was determined.The results showed that the expanded uncertainty was 0.04×10^(6)Da(k=2)when the measurement result is 1.41×10^(6)Da.The uncertainty caused by repeatability was greater.Through the evaluation of measurement uncertainty,the measurement results can be evaluated more objectively and scientifically.

关 键 词：透明质酸钠 平均相对分子质量 不确定度 

分 类 号：TQ658[化学工程—精细化工] O652[理学—分析化学]