正压无创呼吸机治疗阻塞性睡眠呼吸暂停低通气综合征的临床观察  

Clinical Observation on the Treatment of Obstructive Sleep Apnea Hypopnea Syndrome with Positive Pressure Non-Invasive Ventilator

作　　者：冯伟 FENG Wei(Third Internal Medicine Department,Central Hospital of Kazuo County,Liaoning Chaoyang 122300)

机构地区：[1]喀左县中心医院内三科,辽宁朝阳122300

出　　处：《中国医疗器械信息》2023年第7期107-109,共3页China Medical Device Information

摘　　要：目的:分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者疾病特点,评价正压无创呼吸机治疗的临床效果。方法:选择2019年1月~2020年3月本院诊治的80例OSAHS患者,按照入院时间先后进行治疗分组(对照组、观察组)。对照组采取乙酰半胱氨酸泡腾片治疗,观察组患者配合正压无创呼吸机治疗。比较2组OSAS患者的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白水平、睡眠呼吸暂停低通气指数(AHI)、微觉醒指数、Epworth嗜睡量表(The Epworth Sleeping Scale,ESS)评分、最低血氧饱和度(minSpO_(2))。结果:治疗后,观察组患者的TG、TC、LDL-C、IL-6、TNF-α水平均明显低于对照组,HDL-C水平高于对照组,AHI、微觉醒指数、ESS评分均明显高于对照组,minSpO_(2)低于对照组,组间观察指标差异显著,P<0.05。结论:辅助正压无创呼吸机治疗OSAHS预后效果理想,促进患者症状体征改善,降低炎症指标水平。Objective:To analyze the disease characteristics of patients with obstructive sleep apnea-hypopnea syndrome(Obstructive Sleep Apnea-Hypopnea Syndrome,OSAHS),and to evaluate the clinical effects of positive pressure non-invasive ventilator therapy.Methods:80 OSAHS patients diagnosed and treated in our hospital from January 2019 to March 2020 were selected and divided into treatment groups(control group and observation group)according to their admission time.The control group was treated with acetylcysteine effervescent tablets,and the observation group was treated with positive pressure noninvasive ventilator.Compare the triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)、C-reactive protein level,sleep apnea hypopnea index(AHI),arousal index,score of the Epworth Sleeping Scale(ESS),minimum oxygen saturation(minSpO_(2)).Results:After treatment,the levels of TG,TC,LDL-C,IL-6,and TNF-αof the observation group were significantly lower than those of the control group,and the level of HDL-C was higher than that of the control group.AHI,arousal index,and ESS scores were all significantly higher In the control group,minSpO_(2) was lower than that in the control group,and the observed index difference between the groups was significant P<0.05.Conclusion:The prognostic effect of auxiliary positive pressure non-invasive ventilator for OSAHS is ideal,which promotes the improvement of patients’symptoms and signs and reduces the level of inflammation indexes.

关 键 词：正压无创呼吸机 阻塞性睡眠呼吸暂停低通气综合征 Epworth嗜睡量表评分 炎症指标 睡眠呼 吸功能指标 代谢指标 

分 类 号：R452[医药卫生—治疗学]