血清组蛋白去乙酰化酶2、叉头框蛋白A1在子痫前期诊断及妊娠结局评估中的价值  

The significance of serum HDAC2 and FOXA1 expression in the diagnosis,assessment of severity and pregnancy outcome of preeclampsia

作　　者：王宁[1] 周艳[1] 赵磊[1] 陶雅[1] WANG Ning;ZHOU Yan;ZHAO Lei;TAO Ya(Department of Obstetrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州大学第一附属医院产科,河南郑州450000

出　　处：《广东医学》2023年第3期278-283,共6页Guangdong Medical Journal

基　　金：河南省医学科技攻关计划项目(2018020085)。

摘　　要：目的探究血清组蛋白去乙酰化酶2(HDAC2)、叉头框蛋白A1(FOXA1)表达在子痫前期(PE)诊断、严重程度及妊娠结局评估中的价值。方法以分娩的150例PE孕妇(PE组)和100例健康孕妇(对照组)为研究对象,将PE组分为轻度PE(MPE组,n=81),重度PE(SPE组,n=69)。比较不同组别孕妇血清HDAC2、FOXA1水平,然后根据其HDAC2、FDXA1水平把PE孕妇分为HDAC2高表达组(n=72)和HDAC2低表达组(n=78),FOXA1高表达组(n=74)和FOXA1低表达组(n=76)。绘制受试者工作特征(ROC)曲线分析血清HDAC2、FOXA1对PE及不良妊娠结局的预测效能。Spearman相关性分析HDAC2、FOXA1与PE病情的关系。结果PE组血清HDAC2、FOXA1水平均明显低于对照组(P<0.05)。血清HDAC2、FOXA1及联合诊断PE的ROC曲线下面积(AUC)为0.863、0.843、0.912。MPE组血清HDAC2、FOXA1水平明显高于SPE组(P<0.05)。Spearman相关性分析显示,HDAC2、FOXA1均与PE严重程度呈负相关(r=-0.667、-0.712,均P=0.000)。对照组血清HDAC2、FOXA1水平明显高于PE组(P<0.05)。HDAC2低表达组早产儿、肝脏损害、新生儿窒息比例高于HDAC2高表达组(P<0.05)。FOXA1高表达组肝脏损害、早产儿、胸腹腔积液、新生儿窒息比例低于FOXA1低表达组(P<0.05)。血清HDAC2、FOXA1及联合预测PE孕妇不良妊娠结局的AUC为0.788、0.799、0.885。结论PE孕妇血清HDAC2、FOXA1水平与PE病情具有明显负相关性,低水平HDAC2、FOXA1的PE患者不良妊娠结局风险较高,临床可监测HDAC2、FOXA1来辅助诊断PE及预测妊娠结局。Objective To investigate the value of serum histone deacetylase 2(HDAC2)and forkhead box A1(FOXA1)expression in the diagnosis,the assessment of severity and pregnancy outcome of preeclampsia(PE).Methods A total of 150 pregnant women with PE(PE group)and 100 healthy pregnant women(control group)who were delivered in our hospital from January 2021 to February 2022 were enrolled.The PE group was divided into mild PE group(MPE group,n=81)and severe PE group(SPE group,n=69).The levels of serum HDAC2 and FOXA1 of pregnant women among different groups were compared.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of serum HDAC2 and FOXA1 on PE and adverse pregnancy outcomes.Spearman correlation was performed to analyze the correlations between HDAC2,FOXA1 and PE.Results The levels of serum HDAC2 and FOXA1 in the PE group were significantly lower than those in the control group(P<0.05).The areas under the curve of serum HDAC2,FOXA1 and combined diagnosis of PE were 0.863,0.843 and 0.912,respectively.The serum levels of HDAC2 and FOXA1 in the MPE group were significantly higher than those in the SPE group(P<0.05).Spearman correlation analysis showed that HDAC2 and FOXA1 were negatively correlated with the severity of PE(r=-0.667,-0.712,P=0.000).The levels of serum HDAC2 and FOXA1 in the normal pregnancy group were significantly higher than those in the adverse pregnancy group(P<0.05).The proportions of premature infants,liver damage and neonatal asphyxia in the HDAC2 low expression group were significantly higher than those in the HDAC2 high expression group(P<0.05).The proportions of liver damage,premature infants,pleural and ascites,and neonatal asphyxia in the high FOXA1 expression group were significantly lower than those in the low FOXA1 expression group(P<0.05).The areas under the curve of serum HDAC2,FOXA1 and their combination in predicting adverse pregnancy outcomes in PE pregnant women was 0.788,0.799,and 0.885,respectively.Conclusion The serum levels of HDAC2 and FOXA1 in

关 键 词：子痫前期 组蛋白去乙酰化酶2 叉头框蛋白A1 妊娠结局 预测价值 

分 类 号：R714.244[医药卫生—妇产科学] R714.5[医药卫生—临床医学]