辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎有效性及安全性Meta分析  

Efficacy and Safety of Xinqin Granules Combined with H_(1) Receptor Antagonist in the Treatment of Allergic Rhinitis:A Meta-analysis

作　　者：郑诗凯[1] 陆一慧 陈芷新 ZHENG Shikai;LU Yihui;CHEN Zhixin

机构地区：[1]广州市第十二人民医院,广东广州510620 [2]广州中医药大学第一临床医学院,广东广州510405

出　　处：《新中医》2023年第7期48-52,共5页New Chinese Medicine

摘　　要：目的:系统评价辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎的有效性及安全性。方法:计算机检索中国知网(CNKI)、中国生物医学文献数据库(CBM)、万方数据库(Wanfang)、维普中文期刊(VIP)、Cochrane Library、Embase、PubMed数据库中有关辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎的随机对照试验。使用RevMan5.3和Stata15.0软件进行Meta分析。结果:共纳入7篇文献,涉及患者683例。Meta分析显示,辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎总有效率[RR=1.18,95%CI(1.11,1.25),P<0.0001]高于对照组;敏感性分析提示辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎的总有效率结果稳定。辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎的复发率[RR=0.27,95%CI(0.12,0.61),P=0.001]低于对照组,2组不良反应发生率比较,差异无统计学意义[RR=0.61,95%CI(0.26,1.40),P=0.24]。结论:辛芩颗粒联合H_(1)受体拮抗剂治疗变应性鼻炎的临床疗效优于单纯的H_(1)受体拮抗剂治疗,安全性较好。Objective:To systematically evaluate the efficacy and safety of Xinqin Granules combined with H_(1) Receptor Antagonist in the treatment of allergic rhinitis.Methods:The randomized controlled trials of the therapy of Xinqin Granules combined with H_(1) Receptor Antagonist in treating allergic rhinitis were searched from China National Knowledge Network(CNKI),China Biomedical Medicine(CBM),Wanfang Database(Wanfang),VIP Database(VIP),Cochrane Library,Embase and PubMed.A Meta-analysis was performed by using RevMan5.3 and Stata15.0 software.Results:A total of 7 papers were included,involving 683 patients.Meta-analysis showed that the total effective rate of the therapy of Xinqin Granules combined with H_(1) Receptor Antagonist in treating allergic rhinitis[RR=1.18,95%CI(1.11,1.25),P<0.0001]was higher than that in the control group.The sensitivity score suggested that the therapy of Xinqin Granules combined with H_(1) Receptor Antagonist had a stable total effective rate on treating allergic rhinitis.The incidence recurrence of Xinqin Granules combined with H_(1) Receptor Antagonist was lower than that in the control group[RR=0.27,95%CI(0.12,0.61),P=0.001].There was no significant difference between the two groups in the incidence of adverse reactions[RR=0.61,95%CI(0.26,1.40),P=0.24].Conclusion:The therapy of Xinqin Granules combined with H_(1) Receptor Antagonist has a better therapeutic effect on the treatment of allergic rhinitis than the H_(1) Receptor Antagonist alone,which also has great safety.

关 键 词：变应性鼻炎 辛芩颗粒 H_(1)受体拮抗剂 META分析 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]