检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:吴佳波 毛月燕 胡忠华 WU Jiabo;MAO Yueyan;HU Zhonghua
机构地区:[1]杭州市临平区第一人民医院儿科,浙江杭州311100
出 处:《新中医》2023年第7期70-74,共5页New Chinese Medicine
摘 要:目的:观察知柏地黄丸联合达菲林治疗特发性中枢性性早熟女童的临床疗效。方法:将106例特发性中枢性性早熟女童以随机数字表法分为试验组与对照组各53例。对照组给予达菲林治疗,试验组在对照组基础上联用知柏地黄丸治疗。比较2组治疗前后血清性激素水平、生长发育指标、第二性征指标及中医证候积分,并评估2组临床疗效及安全性。结果:试验组总有效率96.23%,高于对照组83.02%(P<0.05)。治疗后,2组血清性激素[黄体生成素(LH)、雌二醇(E_(2))、促卵泡激素(FSH)]水平均较治疗前降低(P<0.05),且试验组治疗后LH、E_(2)、FSH水平低于对照组(P<0.05)。治疗后,2组中医证候积分、骨龄指数、第二性征指标(卵巢体积、子宫体积、乳核直径)均较治疗前降低(P<0.05),且试验组治疗后中医证候积分、骨龄指数及第二性征指标均低于对照组(P<0.05)。治疗后,2组体质量指数(BMI)较治疗前升高(P<0.05),但2组治疗后BMI比较,差异无统计学意义(P>0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:知柏地黄丸联合达菲林治疗特发性中枢性性早熟女童疗效显著,能有效调节患者性激素水平,延缓骨龄成熟,抑制第二性征发育,安全性较高。Objective:To observe the clinical effect of the therapy of Zhibai Dihuang Pills combined with Dipherelin on idiopathic central precocious puberty(ICPP)in girls.Methods:A total of 106 cases of girls with ICPP were divided into the trial group and the control group according to the random number table method,with 53 cases in each group.The control group was treated with Dipherelin,and the trial group was additionally treated with Zhibai Dihuang Pills based on the treatment of the control group.Before and after treatment,the levels of sex hormones,growth and development indexes,secondary sex character indexes and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups.The clinical effects and safety in the two groups were evaluated.Results:The total effective rate was 96.23%in the trial group,higher than that of 83.02%in the control group(P<0.05).After treatment,the levels of serum sex hormones,including luteinizing hormone(LH),estradiol(E_(2))and serum follicle stimulating hormone(FSH)in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of LH,E_(2)and FSH in the trial group were lower than those in the control group(P<0.05).After treatment,the TCM syndrome scores,bone age index and indexes of secondary sex character,including ovarian volume,uterine volume and diameter of mammillary nucleus in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score,bone age index and indexes of secondary sex character in the trial group were lower than those in the control group(P<0.05).After treatment,the Body Mass Indexes(BMI)in the two groups were increased when compared with those before treatment(P<0.05),but there was no significant difference being found in the comparison of BMI between the two groups(P>0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The therapy of Zhibai Dihuang Pills combined with D
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.38