益气活血化痰方联合营养支持治疗慢性阻塞性肺疾病并发急性呼吸衰竭临床研究  

Clinical Study on Yiqi Huoxue Huatan Prescription Combined with Nutrition Support for Chronic Obstructive Pulmonary Disease Complicated with Acute Respiratory Failure

作　　者：曹雅洁 纪元博 李娇娇 CAO Yajie;JI Yuanbo;LI Jiaojiao

机构地区：[1]漯河市第二人民医院,河南漯河462000

出　　处：《新中医》2023年第7期106-110,共5页New Chinese Medicine

基　　金：国家重点研发课题项目(2018YFC1708403)。

摘　　要：目的:观察益气活血化痰方联合营养支持治疗慢性阻塞性肺疾病并发急性呼吸衰竭的临床疗效。方法:将94例慢性阻塞性肺疾病并发急性呼吸衰竭患者按随机数字表法分为对照组与观察组各47例,2组均接受常规治疗+营养支持治疗,观察组再加上益气活血化痰方治疗。比较2组治疗前后淋巴细胞总数(TLC)、血清白蛋白、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SO_(2))、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC及咳痰咳嗽、呼吸困难中医证候积分,比较2组平均住院时间、平均住院费用及病死率、存活率。结果:治疗前,2组TLC、血清白蛋白水平比较,差异无统计学意义(P>0.05);治疗后,2组TLC、血清白蛋白水平均升高,且观察组高于对照组(P<0.05)。治疗前,2组PaO_(2)、PaCO_(2)、SO_(2)、FEV_(1)、FVC、FEV_(1)/FVC比较,差异无统计学意义(P>0.05)。治疗后,2组PaO_(2)均降低(P<0.05),且观察组低于对照组(P<0.05);2组PaCO_(2)、SO_(2)、FEV_(1)、FVC、FEV_(1)/FVC均升高(P<0.05),且观察组高于对照组(P<0.05)。观察组平均住院时间短于对照组(P<0.05),平均住院费用低于对照组(P<0.05)。治疗前,2组咳痰咳嗽、呼吸困难中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组咳痰咳嗽、呼吸困难中医证候积分均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组病死率4.26%,低于对照组19.15%(P<0.05)。结论:将益气活血化痰方联合营养支持应用到慢性阻塞性肺疾病并发急性呼吸衰竭中,可有效提升患者的免疫力,促进血气指标、肺通气功能的恢复,对改善咳痰咳嗽、呼吸困难等症状,缩短住院时间,减少医疗费用,降低病死率等均有重要意义。Objective:To observe the clinical effect of Yiqi Huoxue Huatan Prescription combined with nutrition support on chronic obstructive pulmonary disease(COPD)complicated with acute respiratory failure.Methods:A total of 94 patients with COPD complicated with acute respiratory failure were divided into the control group and the observation group according to the random number table method,with 47 cases in each group.The two groups were given routine treatment and nutrition support,and the observation group was additionally treated with Yiqi Huoxue Huatan Prescription.Before and after treatment,the total lymphocyte count(TLC),serum albumin,partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),oxygen saturation(SO_(2)),forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC and traditional Chinese medicine(TCM)syndrome scores of cough and expectoration,and dyspnea,as well as the average hospitalization time and cost,mortality rate and survival rate were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparisons of the levels of TLC and serum albumin between the two groups(P>0.05);after treatment,the above two levels in both groups were increased,and the above two levels in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of PaO_(2),PaCO_(2),SO_(2),FEV_(1),FVC and FEV_(1)/FVC between the two groups(P>0.05).After treatment,the PaO_(2)levels in the two groups were decreased(P<0.05),and the PaO_(2)level in the observation group was lower than that in the control group(P<0.05);the levels of PaCO_(2),SO_(2),FEV_(1),FVC and FEV_(1)/FVC were increased(P<0.05),and the above five levels in the observation group were higher than those in the control group(P<0.05).The average hospitalization time in the observation group was shorter(P<0.05),and the average hospitalization costs was lower than those in th

关 键 词：慢性阻塞性肺疾病 急性呼吸衰竭 益气活血化痰方 中医证候积分 血气指标 肺通气功能 

分 类 号：R563[医药卫生—呼吸系统]