醒脑开窍针法对急性缺血性脑卒中患者的临床疗效及预后预警模型建立  

Effect of xingnao kaiqiao acupuncture therapy for patient with acute ischemic stroke and the establishment of prediction model for prognosis

作　　者：杨晓晏 朱利莉 钟华[1] 曾秋霞 马晓林 毛翔[1] 范正鹏 廖焦鲁 张福琴[1] Xiao-Yan YANG;Li-Li ZHU;Hua ZHONG;Qiu-Xia ZENG;Xiao-Lin MA;Xiang MAO;Zheng-Peng FAN;Jiao-Lu LIAO;Fu-Qin ZHANG(Acupuncture Department,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院针灸科,重庆400021

出　　处：《World Journal of Acupuncture-Moxibustion》2023年第2期102-110,共9页世界针灸杂志（英文版）

基　　金：Supported by Research on TCM nursing technology promoting rehabilitation of apoplexy patients:YYZX2019063。

摘　　要：ObjectiveTo explore the clinical effectiveness of xingnao kaiqiao (regaining consciousness and opening orifice) acupuncture therapy for patients with acute ischemic stroke, and establish a prediction model for prognosis for the target population through Logistic regression analysis.MethodsNinety-six patients with acute ischemic stroke were randomly assigned to either an ozone therapy group or an ozone therapy plus xingnao kaiqiao acupuncture group (OA group) with a 1:1 ratio. The patients in the ozone group was treated with ozone therapy, and those in the OA group were treated with acupuncture at Nèiguān (内关PC6), Shuĭgōu (水沟GV26), Sānyīnjiāo (三阴交SP6), lower Jíquán (下极泉Extra, lower HT1), Wĕizhōng (委中BL40) and Chĭzé (尺泽LU5) on the basis of the treatment as the ozone therapy group. The treatment was given once daily for 7 days as a session and 3 consecutive sessions were required. Before treatment and 48 h after treatment, the serological indicators (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and hypersensitive C-reactive protein [hs-CRP]) were tested. Using the National Institute of Health stroke scale (NIHSS) score and Montreal cognitive assessment (MoCA) score, the neurological and cognitive functions of patients were assessed. The clinical efficacy was evaluated with the modified Rankin scale, and the incidence of adverse effects was analyzed statistically in two groups. The multivariate Logistic regression analysis was adopted to detect the risk factors of the prognosis in patients and the nomographic prediction model was established.Results(1) clinical therapeutic effect: after treatment, the levels of IL-6, TNF-α and Hs-CRP in the OA group were significantly lower than that in the ozone group (all P < 0.05). After treatment, compared with the ozone therapy group, NIHSS score was lower and the scores of BI and MoCA were significantly higher in the OA group (all P < 0.05). The total effective rate of the OA group was 91.67%, higher than that of the ozone th

关 键 词：Ozone therapy Xingnao kaiqiao acupuncture therapy Acute ischemic stroke Curative effect PROGNOSIS Risk factors Randomized controlled trial(RCT) 

分 类 号：R246.6[医药卫生—针灸推拿学]