针刺对轻度至中度阻塞性睡眠呼吸暂停综合征患者的疗效:一项随机对照临床试验方案  

The efficacy of acupuncture for patients with mild to moderate obstructive sleep apnea syndrome: A protocol for a randomized controlled clinical trial

作　　者：石安琪 王子辰[1] 齐晓环 段莹[2] 王旭 霍建伟 陈懿超 惠志远 王军[1] 闫超群 An-qi SHI;Zi-chen WANG;Xiao-huan QI;Ying DUAN;Xu WANG;Jian-wei HUO;Yi-chao CHEN;Zhi-yuan HUI;Jun WANG;Chao-qun YAN(Department of Acupuncture and Moxibustion,Dongzhimen Hospital Beijing University of Chinese Medicine,Beijing 100700,China;Sleep Medicine Division,Airforce Medical Center,Beijing 100142,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Radiology,Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]北京中医药大学东直门医院针灸科,北京100700 [2]空军总医院睡眠医学中心,北京100142 [3]北京中医药大学生命科学学院,北京100029 [4]首都医科大学北京中医医院放射科,北京100010

出　　处：《World Journal of Acupuncture-Moxibustion》2023年第2期176-183,共8页世界针灸杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China (82004197);Project for New Teachers of Beijing University of Chinese Medicine (2020-JYB-XJSJJ-046)。

摘　　要：Introduction:Obstructive sleep apnea syndrome(OSAS) is considered a major public health issue due to its high prevalence and severe consequences.Several published studies have revealed that electroacupuncture may relieve OSAS symptoms.However,the mechanism of electro-acupuncture in the treatment of patients with OSAS remains unclear.Methods and analysis:We evaluated the efficacy and mechanism of electro-acupuncture in the treatment of patients with OSAS.This was a two-group parallel randomized controlled trial.Sixty patients with OSAS will be randomly divided into an electro-acupuncture or shallow acupuncture group in a proportion of 1:1,and the patients will be administered 36 sessions of electro/shallow acupuncture treatment(three times a week for 12 weeks,20 min for each session).The Epworth Sleepiness Scale(ESS) will be used as the primary outcome.Secondary outcomes will include polysomnography(PSG),sleep quality,emotional state,and cognitive function.In addition,patients will receive neuroimaging scanning before and after the entire acupuncture treatment to evaluate neuroplasticity changes,including gray matter density,white matter integrity,and functional connections.Expected outcomes:We believe that the use of electro-acupuncture will be more effective in patients with mild to moderate OSAS and that the cognitive and emotional status of patients will improve after acupuncture treatment.In addition,we aim to clarify which brain areas can be altered by acupuncture in patients with OSAS.Discussion:This randomized clinical trial aims to explore the curative effect and central mechanism of acupuncture treatment for OSAS.We will explore gray matter density,white matter integrity,and functional connections of the brain using fMRI technology.The results of this study will be significant to the guidelines for clinical OSAS treatment.

关 键 词：Obstructive sleep apnea syndrome ACUPUNCTURE Functional magnetic resonance POLYSOMNOGRAPHY 

分 类 号：R246.81[医药卫生—针灸推拿学]