山东省2017-2021年手足口病流行病学特征及病原学监测分析  

Epidemiological Characteristics and Etiology of HFMD Cases in Shandong Province,China,from 2017 to 2021

作　　者：张元元 王建醒[2] 袁璐 张艺琳 王在翔[1] 寇增强[2] ZHANG Yuanyuan;WANG Jianxing;YUAN Lu;ZHANG Yilin;WANG Zaixiang;KOU Zengqiang(School of Public Health,Weifang Medical College,Weifang 261053,China;Shandong Provincial Center for Disease Control and Prevention,Shandong Academy of Preventive Medicine,Shandong Provincial Key Laboratory of Infectious Disease Prevention and Control,Jinan250014,China)

机构地区：[1]潍坊医学院公共卫生学院,潍坊261053 [2]山东省疾病预防控制中心、山东省预防医学科学院、山东省传染病预防控制重点实验室,济南250014

出　　处：《病毒学报》2023年第2期453-459,共7页Chinese Journal of Virology

基　　金：山东省医药卫生科技发展计划项目(项目号:202012061392),题目:山东省手足口病重症病例流行规律及病原构成研究。

摘　　要：分析2017-2021年山东省手足口病流行趋势及其病原学特征,探讨新冠疫情形势下山东省手足口病疫情发展变化趋势,为制定手足口病防控措施提供科学依据。从中国疾病预防控制信息系统中获取2017-2021年山东省手足口病病例数据和实验室检测数据,采用描述性流行病学方法对其进行分析,共采集28 367例病例标本进行肠道病毒核酸检测。2017-2021年山东省共报告手足口病324 658例,年均发病率为64.65/10万,2018年发病率最高(101.30/10万),其中重症759例,占总病例的0.23%,死亡7例,病死率为0.15%;山东省实验室共检测了28 367例手足口病的病例标本,其他肠道病毒为15 486例(54.59%),EV-A71为5 519例(19.46%),CVA16为7 362例(25.95%)。病例主要集中在每年的7~9月;高发年龄组为0~6岁,占总病例数的90.94%;高发人群以散居儿童、学生、幼托儿童为主,在人群分类里占比分别为67.65%、26.17%以及5.24%;主要病原型别为肠道其他型病毒,占比为54.59%;16地区中济南市发病数最多,占比为16.69%。2017-2021年山东省手足口病发病具有明显的周期性、地域性和人群分布特征,主要病原EV-A71、其他肠道病毒、CVA16交替出现,在高发季节前应对济南、青岛、枣庄等地,散居儿童、学生等重点人群进行宣传预防,为防控手足口病提供科学依据。To analyze the epidemic trend, pathogenic characteristics and the development trend of a hand, foot and mouth disease(HFMD) epidemic in Shandong Province(China) from 2017 to 2021. We also wished to provide a scientific basis for formulating prevention and control measures for HFMD. Case data and laboratorytesting data from 2017 to 2021 in Shandong Province, China were obtained from the Chinese Disease Prevention and Control Information System. We analyzed data by descriptive epidemiological methods, and 28,367 cases were collected for enterovirus(EV) testing. A total of 324,658 cases of HFMD were reported in Shandong Province from 2017 to 2021. The average annual incidence of HFMD was 64.65/10 million populations. The incidence of HFMD in 2018(101.30/100,000) was the highest, and 759 patients had severe HFMD, which accounted for 0.23% of the total number of cases. Seven deaths occurred, and the percentage of fatalities was 0.15%. A total of 28,367 cases of HFMD were tested in the provincial laboratories of Shandong Province, with 1,5,486 cases(54.59%) of other enteroviruses, 5,519 cases(19.46%) of EV-A71, and 7,362 cases(25.95%) of CVA16. Cases were concentrated mainly in July to September each year. The highincidence age group was 0 – 6 years, which accounted for 90.94% of the total number of cases. Children, students and children in care accounted for 67.65%, 26.17% and 5.24% of cases, respectively. The main diseases were caused by intestinal viruses, accounting for 54.59% of cases;in 16 areas, intestinal viruses accounted for 16.69% of cases. In 2017 – 2021, HFMD in Shandong Province had obvious populationdistribution characteristics based on time periods and region. The main pathogen was EV-A71. Our data provide a scientific basis for the prevention and control of HFMD.

关 键 词：手足口病 流行特征 病原学 

分 类 号：R183.4[医药卫生—流行病学] R373.2[医药卫生—公共卫生与预防医学]