关于新型冠状病毒动物宿主和动物感染的研究进展  

Research Progress of SARS-CoV-2 Animal Host and Animal Infection

作　　者：程瑶瑶 陈佳丽 张娜 郭金鹏 陈勇 王长军 CHENG Yaoyao;CHEN Jiali;ZHANG Na;GUO Jinpeng;CHEN Yong;WANG Changjun(School of Public Health,China Medical University,Shenyang 110122,China;Chinese PLA Institute for Disease Control and Prevention,Beijing 100071,China)

机构地区：[1]中国医科大学公共卫生学院,沈阳110122 [2]中国人民解放军疾病预防控制中心,北京100071

出　　处：《病毒学报》2023年第2期528-538,共11页Chinese Journal of Virology

基　　金：北京市科技新星项目(项目号:Z181100006218107)题目:烟曲霉对咪唑类杀菌剂耐药的产生与播散机制研究。

摘　　要：新型冠状病毒(Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)是一种全新的病毒,是继严重急性呼吸综合征冠状病毒(Severe acute respiratory syndrome coronavirus, SARS-CoV)和中东呼吸综合征冠状病毒(Middle East Respiratory Syndrome Syndrome Coronavirus, MERS-CoV)之后引起人类大范围感染的第三种冠状病毒。目前不少研究提示SARS-CoV-2可能来源于动物,动物在疫情的发生与传播过程中起着重要作用。这篇综述总结了目前关于SARS-CoV-2动物宿主和动物易感性的最新研究进展。现有研究提示,SARS-CoV-2很可能起源于蝙蝠,穿山甲是中间宿主。恒河猴,水貂、白尾鹿,动物园里的老虎、狮子,以及宠物猫、狗等动物可能在暴露后发生SARS-CoV-2感染,此外实验室动物感染实验也证明了一些动物对SARS-CoV-2易感,提示下一步需要加强对动物宿主中的SARS-CoV-2监测,为病毒溯源、变异进化规律与传播机制分析以及制定防控措施提供参考。Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is the third coronavirus that causes widespread infection in humans(after SARS-CoV and Middle East Respiratory Syndrome Coronavirus).Several studies have suggested that SARS-CoV-2 may originate from animals, and that animals have an important role in the occurrence and spread of SARS-CoV-2 infection. This review summarizes the latest research progress on the animal hosts of, and animal susceptibility to, SARS-CoV-2. Research suggests that SARS-CoV-2 is likely to originate from bats, and that pangolins are intermediate hosts. Rhesus monkeys, minks, white-tailed deer, tigers, lions in zoos, pet cats, dogs and other animals may develop SARS-CoV-2infection after exposure. Experiments in laboratory animals have shown that some animals are susceptible to SARS-CoV-2. Hence, the next steps should be to strengthen the monitoring of SARS-CoV-2 in animal hosts to provide a reference for the traceability, evolution and transmission mechanism of SARS-CoV-2, and aid formulation of prevention-and-control measures.

关 键 词：SARS-CoV-2 新型冠状病毒感染 动物宿主 易感性 

分 类 号：R373.1[医药卫生—病原生物学]