四次跨膜蛋白在病毒感染中作用的研究进展  

The Roles of Tetraspanins in Viral Infection

作　　者：李婉莹 叶伟 薛亚娟[1] 张芳琳 LI Wanying;YE Wei;XUE Yajuan;ZHANG Fanglin(Department of Pathogen Biology,School of Medicine,Yan'an University,Yan'an 716000,China;Department of Microbiology and Pathogen Biology,School of Basic Medicine,Air Force Military Medical University,Xi'an 710032,China)

机构地区：[1]延安大学医学院病原生物学教研室,延安716000 [2]空军军医大学、基础医学院微生物与病原生物学教研室,西安710032

出　　处：《病毒学报》2023年第2期599-608,共10页Chinese Journal of Virology

基　　金：陕西省科技厅重点研发计划(项目号:2021ZDLSF01-02),题目:重要急性病毒感染发病中单核/巨噬细胞的调控机制及干预策略研究。

摘　　要：四次跨膜蛋白(Tetraspanins,Tspans)是一个作为“细胞膜主要组织者”的跨膜糖蛋白家族。它们与其他膜蛋白横向结合形成富含Tspans的微结构域(Tetraspanin-enriched microdomains,TEMs),在细胞表面建立了独特的平台,从而直接或间接参与病毒感染的多个阶段。Tspans在调控病毒进入、转录、复制和组装释放等阶段均发挥了重要作用。研究Tspans在病毒感染中的作用,可以为病毒感染疾病的临床药物研发提供新靶点。本文综述了Tspans在病毒感染中作用的研究进展。Tetraspanins(Tspans) are a family of transmembrane glycoproteins that act as major organizers of cell membranes. They combine laterally with other membrane proteins to form Tspans-enriched microdomains(TEMs), establishing a unique platform on the cell surface to directly or indirectly participate in multiple stages of viral infection. Tspans play important roles in regulating viral entry, viral transcription and replication, and viral assembly and release. Studying the roles of Tspans in viral infection will provide new targets for clinical vaccine and drug development of viral infectious diseases. In this work, we review recent research advances on the roles of Tspans in viral infection.

关 键 词：四次跨膜蛋白 病毒感染 

分 类 号：R373.9[医药卫生—病原生物学]