单核细胞分布宽度在脓毒症早期诊断和预后评估中的研究进展  

Research progress of monocyte distribution width in early diagnosis and prognostic assessment of sepsis

作　　者：于佳琪 梁群[2] 刘雨默 刘洋[1] 李鹤然 YU Jiaqi;LIANG Qun;LIU Yumo;LIU Yang;LI Heran(The First Clinical Medical College,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150000,China;Department of Critical Medicine,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150000,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江哈尔滨150000 [2]黑龙江中医药大学附属第一医院重症医学科,黑龙江哈尔滨150000

出　　处：《中国医药导报》2023年第12期40-43,47,共5页China Medical Herald

基　　金：国家自然科学基金面上项目(81974557)。

摘　　要：脓毒症是急诊、重症科室病死率较高的疾病之一,早期识别、诊断、干预治疗能有效降低发病率和死亡率。目前用于脓毒症的生物标志物均存在一定局限性。单核细胞分布宽度是一种新的细胞测量参数,研究发现,当单核细胞被激活时,其形态异质性可用于脓毒症早期诊断和预后评估。本文将对单核细胞分布宽度在感染中的形态变化、检测方法、基础研究、参考范围等进行简要综述,以期为脓毒症的早期诊断及预后评估作临床参考。Sepsis is one of the diseases with high mortality in emergency department and intensive care department,early identification,diagnosis,and intervention can effectively reduce incidence rate and mortality.At present,biomarkers used for sepsis have certain limitations.Monocyte distribution width is a new cell measurement parameter.Studies have found that when monocytes are activated,their morphological heterogeneity can be used for early diagnosis and prognosis evaluation of sepsis.This article will briefly review the morphological changes,detection methods,basic research,and reference range of monocyte distribution width in infection in order to provide clinical reference for the early diagnosis and prognosis evaluation of sepsis.

关 键 词：脓毒症 单核细胞分布宽度 标志物 诊断 

分 类 号：R631[医药卫生—外科学]